Abstract: Tumor dormancy is a state that tumor cells longterm exist in human body, without obvious growth. Dormant cell is one of the origins of tumor recurrence or metastasis. The exact mechanism of tumor dormancy is still unclear. Combined with cellular and molecular biological techniques, tumor cell transplantation and culture in vitro can establish experimental tumor dormancyrecurrence models. These in vivo and in vitro models can be used to investigate mechanisms of tumor dormancy and to explore novel treatments.

Key words: Neoplasms, experimental, Models, animal, Dormancy period