Abstract: As one of the Cdc25 phosphatase family members, Cdc25C plays an important role in regulating mitosis of eukaryotic cells.In eukaryotic cells, CDK1cell cycle protein B (CyclinB) compound mainly control the process of G2M. The activity of Cdc25C is the key in cell cycle into M phase. It activates CDK1cyclinB complexes to promote cells from G2 to M phase . Improving Cdc25C activity can promote the G2M phase transition, and remove the G2M phase retardation induced by ionizing radiation, preventing the damaged DNA from repaired into the phase of cell division, resulting in cell death caused by excessive cell proliferation, thus enhance radiosensitivity.

Key words: Cdc25 phosphatases, Radiation tolerance, Neoplasms, Cell cycle