Mechanism and research progress of ferroptosis in cervical cancer treatment

doi:10.3760/cma.j.cn371439-20250901-00135

Abstract

Abstract:

The pathological progression of cervical cancer is closely related to iron metabolism regulation and oxidative stress. Ferroptosis， as a form of iron-dependent programmed cell death， has a significant association with the occurrence and development of cervical cancer. Unlike traditional cell death pathways such as apoptosis and necrosis， ferroptosis shows distinct specificity. Its main characteristics include lipid peroxidation， iron accumulation， and inhibition of the antioxidant system. Ferroptosis has shown excellent efficacy in antitumor treatment and has promising application prospects. When combined with traditional methods such as radiotherapy and chemotherapy， it demonstrates potential for synergistic enhancement. Further exploration of the molecular basis and research advances in the relationship between ferroptosis and cervical cancer， and delving into its underlying mechanism of action， can provide a theoretical foundation and practical guidance for innovative treatment strategies for cervical cancer.

Key words: Uterine cervical neoplasms, Ferroptosis, Lipid peroxidation, Antineoplastic protocols

Hou Xiaoxuan, Tang Wenjie, Xie Peng. Mechanism and research progress of ferroptosis in cervical cancer treatment[J]. Journal of International Oncology, 2025, 52(12): 791-794.

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