Research progress on combined radiotherapy， chemotherapy， and immunotherapy for cervical cancer

doi:10.3760/cma.j.cn371439-20250619-00124

Abstract

Abstract:

In clinical studies of cervical cancer， the combination of radiotherapy， chemotherapy， and immunotherapy has yielded certain results. Programmed death-1/programmed death-ligand 1 inhibitors have also demonstrated positive results in multiple clinical trials. Novel immunotherapies such as human papillomavirus peptide vaccines， DNA vaccines， tumor-infiltrating lymphocyte therapy， and bispecific antibodies have been applied in the treatment of recurrent or metastatic cervical cancer， demonstrating significant anti-tumor activity， the potential to reshape the immune microenvironment， adaptability to personalized treatment， and synergistic effects when combined with multi-modal therapies. A deeper exploration of the synergistic mechanisms of combined therapy regimens and the application and development limitations of various therapies in cervical cancer treatment can provide insights for further optimizing treatment strategies for cervical cancer.

Key words: Uterine cervical neoplasms, Immunotherapy, Chemoradiotherapy, Tumor microenvironment, PD-1/PD-L1 inhibitors

Ma Yongjia, Peng Siyu, Sun Pengfei. Research progress on combined radiotherapy， chemotherapy， and immunotherapy for cervical cancer[J]. Journal of International Oncology, 2025, 52(11): 726-731.

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