Journal of International Oncology ›› 2024, Vol. 51 ›› Issue (6): 350-353.doi: 10.3760/cma.j.cn371439-20240218-00060

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Role of PFDN and its subunits in tumorigenesis and tumor development

Guo Zehao, Zhang Junwang()   

  1. Department of Gastroenterology, Second Hospital of Shanxi Medical University, Taiyuan 030000, China
  • Received:2024-02-18 Revised:2024-03-10 Online:2024-06-08 Published:2024-06-28
  • Contact: Zhang Junwang, Email: jasong@sxmu.edu.cn
  • Supported by:
    Natural Science Foundation of Shanxi Province of China(201801D121327)

Abstract:

Prefoldin (PFDN) acts as a co-companion protein to stabilize newly synthesized peptides and prevent protein misfolding and aggregation. PFDN plays an important role in cytoskeleton formation. PFDN is upregulated in glioma, breast cancer, lung cancer, gastric cancer, liver cancer, colorectal cancer and other tumor tissues and is closely linked with the proliferation and migration of tumor cells. A deeper understanding of the role of PFDN in tumorigenesis and development may provide new ideas and insights for PFDN in preventing or reversing tumor progression.

Key words: Neoplasms, Carcinogenesis, Prefoldin