Senotherapies in cancers

doi:10.3760/cma.j.cn371439-20230606-00138

Abstract

Abstract:

Cancer cells have a senescence response， and senescence in cancer cells have both tumor-suppressive and tumor-promoting effects. Cancer senotherpy includes pro-senescent cancer therapy， senolytic therapy and senomorphic therapy. However， the efficacy and adverse effects need to be thoroughly studied. Detection of senescence-associated proteins and metabolites within the patients' cancer senescent cells and peripheral blood may help to evaluate the efficacy of senotherapy and guide future clinical trials.

Key words: Neoplasms, Cellular senescence, Therapy

Yue Hongyun, Zhang Baihong. Senotherapies in cancers[J]. Journal of International Oncology, 2023, 50(12): 734-738.

Figures/Tables 1

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药物类别	作用机制	临床前研究应用	临床试验
Bcl-2抑制剂	抑制Bcl-2通路	联合化疗药物应用于乳腺癌和肺癌细胞株及异种移植模型	Ⅰ期^[20,23]
mTOR抑制剂	抑制mTOR通路	分别联合多西他赛和氟尿嘧啶应用于前列腺癌和乳腺癌细胞株及异种移植模型	Ⅰ期^[15]
抗PD-1/PD-L1抗体	T细胞免疫反应	联合化疗或CDK4/6抑制剂应用于实体瘤模型	Ⅱ期^[26]