Methyltransferase like protein 14 and tumor

doi:10.3760/cma.j.cn371439-20220511-00092

Abstract

Abstract:

N⁶-methyladenosine （m⁶A） modification, as the most prevalent epigenetic modification of RNA, plays a crucial role in the initiation and development of malignancies. Methyltransferase like protein 14 （METTL14） is a major methylase catalyzing m⁶A modification and regulating biological processes such as RNA splicing, translation and degradation. Recent studies have demonstrated that METTL14 not only regulates the growth, invasion and metastasis of tumors through various molecular mechanisms, but also is closely correlated with the prognosis of tumor patients and clinical efficacy of anti-tumor therapies. In-depth understanding of the mechanism of METTL14 in breast, digestive system and urinary system tumors is helpful to provide new clinical markers and drug targets for the prevention and treatment of tumors based on m⁶A modification.

Key words: Neoplasms, N⁶-methyladenosine, Methyltransferase like protein 14, Signaling pathway, Biomarkers

Hu Ru, Li Donglin, Yan Xuebing. Methyltransferase like protein 14 and tumor[J]. Journal of International Oncology, 2022, 49(8): 478-483.

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