Advances in the amplification of HER2 in metastatic colorectal cancer

doi:10.3760/cma.j.cn371439-20200715-00049

Abstract

Abstract:

Several studies have shown that human epidermal growth factor receptor 2 (HER2) amplification could be a predictive biomarker of resistance to anti-epidermal growth factor receptor monoclonal antibodies in patients with RAS wild-type metastatic colorectal cancer (mCRC). Dual HER2 inhibition with trastuzumab plus lapatinib or pertuzumab has shown promising preliminary anti-tumoral efficacy in RAS wild-type mCRC. HER2-targeted therapeutic strategies have the potential to change the treatment paradigm for a clinically relevant subgroup of patients with mCRC.

Key words: Colorectal neoplasms, Genes, erbB-2, Biomarkers, Molecular targeted therapy

Yu Jiaojiao, Wang Jun, Wang Likang, Yao Nan. Advances in the amplification of HER2 in metastatic colorectal cancer[J]. Journal of International Oncology, 2021, 48(4): 246-249.

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