Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (6): 442-.doi: 10.3760/cma.j.issn.1673-422X.2017.06.010

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Research progress of Dickkopf1 related tumor metastasis

Zhu Qiumei, Zhang Yong   

  1. Department of Traditional Chinese Medicine Oncology, Central Hospital of Putuo District of Shanghai, Shanghai 200062, China
  • Online:2017-06-08 Published:2017-06-16
  • Contact: Zhang Yong E-mail:zhangyong75@msn.com
  • Supported by:

    National Natural Science Foundation of China (81273733)

Abstract: As a secreted glycoprotein, Dickkopf1 (DKK1) is closely related to tumor metastasis, and it is highly or lowly expressed in tumor. The high expression of DKK1 promotes the metastasis of a variety of malignant tumors including liver cancer, gastric cancer, nonsmall cell lung cancer and breast cancer. Recent studies have found that DKK1 is inextricably bound up with the latent metastasis of tumor.

Key words: Neoplasm metastasis, Therapy, Dickkopf-1