Protein S-palmitoylation and its role in tumor

doi:10.3760/cma.j.cn371439-20240522-00130

Abstract

Abstract:

Protein S-palmitoylation is a reversible post-translational modification of lipids that regulates protein localization， stability and protein-protein interactions. The thioesterification of palmitate to internal cysteine residues is catalyzed by palmitoyltransferase， while the removal of palmitate is mainly catalyzed by acyl-protein thioesterase. The S-palmitoylation of some tumor-related proteins is abnormally altered in tumor， which is closely related to the biological processes such as tumor cell proliferation， invasion， metastasis， drug resistance and immune response. Furtherly， exploring the characteristics of protein S-palmitoy-lation and its role in tumor progression could deliver new ideas in targeting protein S-palmitoylation for tumor therapy.

Key words: Neoplasms, Protein processing， post-translational, S-palmitoylation, Palmitoyltransfe-rases, Acyl-protein thioesterases

Chen Liang, Li Yingge, Zheng Sihao, Zhang Cai, Yan Qilu, Song Qibin, Yao Yi. Protein S-palmitoylation and its role in tumor[J]. Journal of International Oncology, 2024, 51(12): 769-773.

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