Mechanism of hydrogen sulfide in tumorigenesis and development and its donor-mediated anti-tumor effects

doi:10.3760/cma.j.cn371439-20230605-00137

Abstract

Abstract:

Hydrogen sulfide is a gas signaling molecule in the human body that can influence angiogenesis， regulate tumor cell apoptosis and autophagy， and interact with other signaling molecules in the tumor microenvironment. It plays a role in inhibiting tumorigenesis and development through various pathways. Hydrogen sulfide donors primarily exhibit anti-tumor effects， and many studies are focused on using various donors to release hydrogen sulfide in a controlled manner and maintain therapeutic concentrations. Traditional Chinese medicine shows great potential. The mechanisms of hydrogen sulfide action are complex and diverse， and further research is needed to explore and confirm them， providing a theoretical basis for the development of therapeutic drugs regulating hydrogen sulfide.

Key words: Neoplasms, Hydrogen sulfide, Blood vessels, Apoptosis, Autophagy, Tumor microenvironment

Zhu Yi, Chen Jian. Mechanism of hydrogen sulfide in tumorigenesis and development and its donor-mediated anti-tumor effects[J]. Journal of International Oncology, 2023, 50(12): 729-733.

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