Journal of International Oncology ›› 2016, Vol. 43 ›› Issue (2): 126-.

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Discoidin domain receptor 2 and its expression and role in tumor

WANG  Lei, LIU  Dong-Ming   

  1. Department of Urology Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China
  • Online:2016-02-08 Published:2015-12-28

Abstract: Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase (RTK) that can be activated by fibrillar collagens (ⅠⅢ , Ⅹ).Recently researchers show that the DDR2 is expressed differently in many cancers,which suggests DDR2 is probably correlated with tumorigenesis and cancer development,and it may become a promising cancer therapeutic target.

Key words: Collagen, Neoplasms, Discoidin domain receptor 2