Proto-oncogene Bmi-1 and non-small cell lung cancer

doi:10.3760/cma.j.issn.1673-422X.2015.04.015

Abstract

Abstract: B-cell specific moloney leukemia virus insertion site 1 (Bmi-1)gene is a core member of the polycomb group genes, considered to be a proto-oncogene; Bmi-1 plays an important role in cell selfrenewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in non-small cell lung cancer; furthermore, the expression level of Bmi-1 is closely related to the occurrence, development, incursion and prognosis of nonsmall cell lung cancer. Bmi-1 is expected to become a novel tumor molecular marker, and provides a new direction for the treatment of non-small cell lung cancer.

Key words: Proto-oncogene, Carcinoma, non-small-cell lung, Bmi-1

LAI Xiang-Li-；Feng-Guo-Sheng. Proto-oncogene Bmi-1 and non-small cell lung cancer[J]. Journal of International Oncology, 2015, 42(4): 295-297.

References

［1］ Yadirgi G, Leinster V, Acquati S, et al. Conditional activation of Bmil expression regulates selfrenewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo［J］. Stem Cells, 2011, 29(4): 700712. ［2］ Cohen KJ, Hanna JS, Prescott JE, et al. Transformation by the Bmi1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity［J］. Mol Cell Biol, 1996, 16(10): 55275535. ［3］ Xin T, Zhang FB, Sui GJ, et al. Bmi1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity［J］. Br J Biomed Sci, 2012, 69(2): 6266. ［4］ Alkema MJ, Wiegant J, Raap AK, et al. Characterization and chromosomal localization of the human protooncogene Bmi1［J］. Hum Mol Genet, 1993, 2(10) : 15971603. ［5］高珊, 王仁生. 原癌基因Bmi1与头颈部恶性肿瘤［J］. 国际肿瘤学杂志, 2013, 40(9): 665668. ［6］ Lee K, Adhikary G, Balasubramanian S, et al. Expression of Bmi1 in epidemis enhances cell survivalby altering cell cycle regulatory protein expression and inhibiting apoptosis［J］. J Invest Dennatol, 2008, 128(1): 910. ［7］ Vonlanthen S, Heighway J, Altermatt HJ, et al. The Bmi1 oncoprotein is differentially expressed in non small cell lung cancer and correlates with INK4AARF locus expression［J］. Br J Cancer, 2001, 84(10): 13721376. ［8］ Hu J, Liu YL, Piao SL, et al. Expression patterns of USP22 and potential tmgets Bmi1, trPEN, PAKT in non small cell lung cancer［J］. Lung Cancer, 2012, 77(3): 593599. ［9］ Tátrai P, Szepesi , Matula Z, et al. Combined introduction of Bmi1 and hTERT immortalizes human adipose tissuederived stromal cells with low risk of transformation［J］. Biochem Biophys Res Commun, 2012, 422(1): 2835. ［10］ Silva J, García JM, Pea C, et al. Implication of polycomb members Bmi1, Mel18, and Hpc2 in the regulation of p16INK4a, p14ARF, hTERT, and cmyc expression in primary breast carcinomas［J］. Clin Cancer Res, 2006, 12(23): 69296936. ［11］ Datta S, Hoenerhoff MJ, Bommi P, et al. Bmi1 cooperates with HRas to transform human mammary epithelial cells via dysregulation of multiple growthregulatory pathways［J］. Cancer Res, 2007, 67(21): 1028610295. ［12］ Silva J, García V, García JM, et al. Circulating Bmi1 mRNA as a possible prognostic factor for advanced breast cancer patients［J］. Breast Cancer Res, 2007, 9(4): R55. ［13］郑翔宇, 朱杰. Bmi1siRNA对肺腺癌A549细胞体内外增殖能力的影响［J］. 中国癌症杂志, 2013, 23(7): 505511. ［14］ Yu Q, Su B, Liu D, et al. Antisense RNAmediated suppression of Bmil gene expression inhibits the proliferation of lung cancer cell line A549［J］. Oligonucleotides, 2007, 17(3): 327335. ［15］ Meng X, Wang Y, Zheng X, et al. shRNAmediated knockdown of Bmi1 inhibit lung adenocarcinoma cell migration and metastasis［J］. Lung Cancer, 2012, 77(1): 2430. ［16］刘春灵, 宋文刚, 李惠翔. Bmi1在非小细胞肺癌组织中的表达和意义［J］. 当代医学, 2012, 18(2): 46. ［17］项锋钢, 党受琴, 冉雯雯, 等. 非小细胞肺癌组织 Bmi1与Cmyc蛋白表达及其相关性［J］. 青岛大学医学院学报, 2011, 47(3): 204209. ［18］ Hu J, Liu YL, Piao SL, et al. Expression patterns of USP22 and potential targets BMI1, PTEN, pAKT in nonsmallcell lung cancer［J］. Lung Cancer, 2012, 77(3): 593599. ［19］赵均生, 陈晓燕. Bmi1 在非小细胞肺癌中的表达及其与p16相关性分析［J］. 中国临床新医学, 2013, 6(4): 334337. ［20］唐甜, 陕光. Bmi1和EZH2基因在小细胞肺癌中的表达及其意义［J］. 中国组织化学与细胞化学杂志, 2012, 21(1): 4851. ［21］ Breuer RH, Snijders PJ, Sutedja GT, et al. Expression of the p16(INK4a) gene product, methylation of the p16(INK4a) promoter region and expression of the polycomb group gene BMI 1 in squamous cell lung carcinoma and premalignant endobronchial lesions［J］. Lung Cancer, 2005, 48(3): 299306. ［22］张萌萌, 项锋钢, 冉雯雯, 等. 非小细胞肺癌组织Bmi1表达与上皮间质转化关系［J］. 齐鲁医学杂志, 2012, 27(2): 101106. ［23］李白翎, 金磊, 钟铿. 非小细胞肺癌组织Bmi1和VEGF表达及其临床意义的研究［J］. 中华肿瘤防治杂志, 2012, 19(21): 16111613.

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[4]	Yu Jinjing, Lai Chunyun. Expression and function of c-Myc in tumor [J]. Journal of International Oncology, 2017, 44(4): 278-280.
[5]	Teng Fei, Cui Guimin, Shi Hongyun, Liu Miaoling, Li Yanhong. Clinical observation of radiotherapy combined with temozolomide in non-small cell lung cancer patients with brain metastases [J]. Journal of International Oncology, 2017, 44(4): 271-273.
[6]	YAN Da-Li, CAO Hai-Xia, FENG Ji-Feng. Advances of long non-coding RNA UCA1 in cancers [J]. Journal of International Oncology, 2017, 44(2): 108-111.
[7]	Guo Hongyan, He Lizhen, Zhang Yunfei, Zhang Hong, Jin Huiqin, An Wenwen. Metastasis-associated in colon cancer 1 and its role in cancer [J]. Journal of International Oncology, 2016, 43(1): 32-35.
[8]	Fang Jianchen, Li Zheng, Xia Zhaoxia, Zhang Huizhi. Expression and significance of MYC/BCL2 protein coexpression in diffuse large B-cell lymphoma [J]. Journal of International Oncology, 2014, 41(8): 712-714.
[9]	GAO Shan, WANG Ren-Sheng. Proto-oncogene Bmi-1 and head and neck cancer [J]. Journal of International Oncology, 2013, 40(8): 665-668.
[10]	XIONG Bei-Bei, FAN Hua, LI Tao. Bmi-1 gene and radiation resistance [J]. Journal of International Oncology, 2013, 40(3): 184-186.
[11]	LIANG Zhi-Jie, JIA Miao-Miao, ZHANG Bin, et al . Roles of Pim-1 in tumors and related signaling pathways [J]. Journal of International Oncology, 2013, 40(10): 723-726.
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