The change of target area and the surrounding structure during the intensity modulated radiotherapy of nasopharyngeal carcinoma

doi:10.3760/cma.j.issn.1673-422X.2015.04.014

Abstract

Abstract: 【Abstract】Intensity modulated radiation therapy (IMRT) has become the mainstay of treatment modality for nasopharyngeal carcinoma (NPC). The whole treatment course generally continues 7 to 8 weeks. With the radiotherapy proceeding, the patients exhibit oropharyngeal reaction aggravating, weight losing and tumor shrinking, resulting in the changes of tumor target and surrounding tissue. Those changes may influence the dose distribution of tumor and organ at risk. It is necessary to modulate target volume during radiotherapy of NPC.

Key words: Nasopharyngeal neoplasms, Radiotherapy planning, computerassisted, Organ at risk

FAN Ting-Yong-；Li-Jian-Bin-；Yu-Jin-Ming. The change of target area and the surrounding structure during the intensity modulated radiotherapy of nasopharyngeal carcinoma[J]. Journal of International Oncology, 2015, 42(4): 292-294.

References

1］ Yang BB, Wang J, Zhong RM, et al. Volumetric and geometric changes of parotids occurring during IMRT for nasopharyngeal carcinoma (NPC) using daily CBCT［J］. Sichuan Da Xue Xue Bao Yi Xue Ban, 2010, 41(6): 10241028. ［2］ Orlandi E, Tomatis S, Potepan P, et al. Critical analysis of locoregional failures following intensitymodulated radiotherapy for nasopharyngeal carcinoma［J］. Future Oncol, 2013, 9(1): 103114. ［3］ Lu H, Lin H, Feng G, et al. Interfractional and intrafractional errors assessed by daily conebeam computed tomography in nasopharyngeal carcinoma treated with intensitymodulated radiation therapy: a prospective study［J］. J Radiat Res, 2012, 53(6): 954960. ［4］ Vila Capel A, Vilar Palop J, Pedro Olivé A, et al. IMRT: preliminary results in a series of advanced headandneck cancer patients［J］. Clin Transl Oncol, 2013, 15(3): 233242. ［5］ Barker JL Jr, Garden AS, Ang KK, et al. Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for headandneck cancer using an integrated CT/linear accelerator system［J］. Int J Radiat Oncol Biol Phys, 2004, 59(4): 960970. ［6］曹建忠, 罗京伟, 徐国镇, 等. 鼻咽癌调强放疗中靶区和正常器官变化规律及临床意义探讨［J］. 中华放射肿瘤学杂志, 2007, 16(2): 8185. ［7］ Lu N, Feng LC, Cai BN, et al. Clinical study on the changes of the tumor target volume and organs at risk in helical tomotherapy for nasopharyngeal carcinoma［J］. Chin Med J (Engl), 2012, 125(1): 8790. ［8］ Chen C, Lin X, Pan J, et al. Is it necessary to repeat CT imaging and replanning during the course of intensitymodulated radiation therapy for locoregionally advanced nasopharyngeal carcinoma?［J］. Jpn J Radiol, 2013, 31(9): 593599. ［9］ Hansen EK, Bucci MK, Quivey JM, et al. Repeat CT imaging and replanning during the course of IMRT for headandneck cancer［J］. Int J Radiat Oncol Biol Phys, 2006, 64(2): 355362. ［10 ］卢洁, 尹勇, 范廷勇, 等. 鼻咽癌调强放疗中实施同一计划对剂量的影响［J］. 中华放射医学与防护杂志, 2008, 28(5): 456458. ［11］王震吾, 王明智, 杨波, 等. 鼻咽癌调强适形放疗中正常器官体积剂量变化的研究［J］. 实用临床医药杂志, 2011, 15(1): 6266. ［12］ Bar T, Zagury A, London D, et al. Calcifications simulating sialolithiasis of the major salivary glands［J］. Dentomaxillofac Radiol, 2007, 36(1): 5962. ［13］ Han C, Chen YJ, Liu A, et al. Actual dose variation of parotid glands and spinalcord for nasopharyngeal cancer patients during radiotherapy［J］. Int J Radiat Oncol Biol Phys, 2008, 70(4): 12561262. ［14］ SenkusKonefka E, Naczk E, Borowska I, et al. Changes in lateral dimensions of irradiated volume and their impact on the accuracy of dose delivery during radiotherapy for head and neck cancer［J］. Radiother Oncol, 2006, 79(3): 304309. ［15］曹建忠, 罗京伟, 徐国镇, 等. 鼻咽癌调强放疗中解剖及剂量学改变再次计划必要性研究［J］. 中华放射肿瘤学杂志, 2008, 17(3): 161164. ［16］黄邵敏, 邓小武, 赵充, 等. 鼻咽癌调强放疗中解剖结构改变对剂量分布影响研究［J］. 中华放射肿瘤学杂志, 2010, 19(5): 404408.

[1]	Xu Fenglin, Wu Gang. Research progress of EBV in tumor immune microenvironment and immunotherapy of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2024, 51(6): 359-363.
[2]	Gu Anqin, Long Jinhua, Jin Feng. Clinical research progress of immunotherapy for nasopharyngeal carcinoma [J]. Journal of International Oncology, 2023, 50(5): 299-303.
[3]	Chen Fangming, Cai Yuanyuan, Li Han, Wang Xiaoli, Kan Hongxing, Li Yang, Hao Furong, Wang Mingchen. Prognostic differences of nasopharyngeal carcinoma patients treated with intensity-modulated radiothe-rapy with different T staging of the seventh and eighth edition of the UICC staging system [J]. Journal of International Oncology, 2021, 48(9): 515-522.
[4]	Peng Ya, Liu An, Liu Huowang. Inhibitory effect and mechanism of PSD-007 photodynamic therapy on human nasopharyngeal carcinoma transplanted tumors in nude mice [J]. Journal of International Oncology, 2021, 48(3): 136-142.
[5]	Zhu Lei, Huang Jianbo. Effects of Epstein-Barr virus DNA load and different treatment methods on the therapeutic effect and prognosis of stage Ⅲ nasopharyngeal carcinoma [J]. Journal of International Oncology, 2021, 48(2): 74-79.
[6]	Luo Wenxiao, Wu Dehua, Cai Longmei. Prognostic values of immune efficacy biomarkers in the treatment of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2021, 48(12): 743-746.
[7]	Yang Minghui, Jin Feng. Value of 3D-ASL, MRS and DTI in the diagnosis and treatment of radiation-induced temporal lobe injury of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2020, 47(9): 550-554.
[8]	Yang Chao, Wang Jianbo, Zhang Juhong, Wang Jialong. Overexpression of miR-125 inhibits proliferation and invasion of nasopharyngeal carcinoma cells by down-regulating FGF-2 [J]. Journal of International Oncology, 2020, 47(5): 257-263.
[9]	Shen Jianjun. Treatment of local recurrenct nasopharyngeal carcinoma after radiotherapy [J]. Journal of International Oncology, 2020, 47(4): 227-230.
[10]	Zhou Yuanyuan, Li Jing. Clinical practice value of hematological inflammation biomarkers in nasopharyngeal carcinoma [J]. Journal of International Oncology, 2019, 46(8): 492-495.
[11]	Zhou Ping, Chen Weisi, Zhang Shuang, Lin Bing, Pan Tao, Liu Sha. Observation of efficacy of paclitaxel with concurrent radiotherapy in the treatment for nasopharyngeal carcinoma patients with liver metastasis [J]. Journal of International Oncology, 2019, 46(6): 327-330.
[12]	CHEN Jiong-Yu, ZHUANG Yi-Xuan, ZHUANG Shan-Shan, PENG Lin. Effects of osthole on the proliferation, invasion and migration of nasopharyngeal carcinoma cells CNE2 [J]. Journal of International Oncology, 2018, 45(8): 453-459.
[13]	LAI Shi-Jia, ZHAO De-An, SUN Yong-Ming. Expression and clinical significance of serum microRNA663 in nasopharyngeal carcinoma patients [J]. Journal of International Oncology, 2018, 45(8): 460-464.
[14]	Huang Ting, Song Xuewei, An Shufen, Wang Zhibin, Liao Hehe. Expressions of MDR-1 and P-gp in human nasopharyngeal squamous cell carcinoma CNE1 cell line after X-ray exposure [J]. Journal of International Oncology, 2018, 45(6): 321-324.
[15]	Huang Can, Chen Qiuyan, Zuo Feifei, Peng Chuan, Zhong Shaobin, Mai Haiqiang, Chen Mingyuan, Zou Ruhai. Diagnostic value of lymph node EBV-DNA detection in cervical lymph node metastasis of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2018, 45(3): 143-147.