Abstract: One leading research target of modern tumor radiotherapy is to increase radiosensitization of tumor and improve curative effect of radiotherapy. Histone deacetylase inhibitors are epigenetic drugs that can play a part in radiosensitization through means of induction of apoptosis, inhibition of repair of DNA doublestrand breaks, cell cycle arrest, improvement of tumor cell hypoxia and increase of reactive oxygen species. There is an urgent need to develop biomarkers based on these pathways, which can promote clinically individualized treatment.

Key words: Histone deacetylases, Protease inhibitors, Radiationsensitizing agents, Neoplasms