Hypoxia-inducible factor-1 and transforming growth factor-β in tumor

Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (8): 652-655.

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Hypoxia-inducible factor-1 and transforming growth factor-β in tumor

GAO Chao, FENG Xiang-Ying

Department of Neurology, Xinhua Hospital, Dalian University, Dalian 116021, China

Online:2013-09-08 Published:2013-09-16
Contact: Corresponding author: FENG Xiang-ying, E-mail: daiyue315@126.com E-mail:daiyue315@126. com

Abstract

Abstract: Hypoxia-inducible factor-1 (HIF-1) is one of the most important hypoxia signal transmission factor, and it has been observed in many human tumors. HIF-1 could play a role of promoting tumor by regulating the expression level of transforming growth factor-β in vivo and in vitro, and then affecting the development and prognosis of tumor.

Key words: Hypoxia-inducible factor-1, Transforming growth factor-β, Neoplasms, Vascular endothelial growth factors

GAO Chao, FENG Xiang-Ying. Hypoxia-inducible factor-1 and transforming growth factor-β in tumor[J]. Journal of International Oncology, 2013, 40(8): 652-655.

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Hypoxia-inducible factor-1 and transforming growth factor-β in tumor

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