MLL2 gene and tumors

Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (8): 569-571.

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MLL2 gene and tumors

LIU Bei-Chen, MA Guang-Yu, GAO Yu-Huan

Department of Hematology, the Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang Hebei 050035, China

Online:2013-08-08 Published:2013-08-15
Contact: Corresponding author：GAOYu-huan, E-mail: ydsygao@sina.com E-mail:ydsygao@sina.com

Abstract

Abstract: Histone methyltransferase modulates heterochromatin formation, genomic imprinting and genetic transcription by regulating the combination of histones and DNA. As encoding genes of histone methyltransferase, mixed-lineage leukemia (MLL) genes are found to have close relationship with tumors. Recently, MLL2, a member of this family, has been found highly expressed anomalously in breast cancer, colorectal cancer and lymphoma. Whether MLL2 participates in the progression of cancer, the time phase of its participation and its specific role are still remained to further study.

Key words: Neoplasms, Lymphoma, MLL2 gene

LIU Bei-Chen, MA Guang-Yu, GAO Yu-Huan. MLL2 gene and tumors[J]. Journal of International Oncology, 2013, 40(8): 569-571.

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