Abstract: The G protein-coupled receptor family C, member 5, group A (GPRC5A) gene is known as retinoic acid-induced gene, which is mainly distributed in lung tissue. The expression of GPRC5A in lung cancer is significantly decreased compared with normal lung. GPRC5A leads to lung cancer through knockout mice, which is proven to be a suppressor gene of lung cancer. GPRC5A may be a novel biomarker for the diagnosis of lung cancer and a new target for the treatment of lung cancer.

Key words: Lung neoplasms, Receptors, G-protein-coupled