Abstract: Peroxisome proliferator activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays a critical role in regulating glucose and lipid homeostasis, and in the processes of tumor cell proliferation, differentiation, apoptosis, invasion and distant metastasis. Studies demonstrate that PPARγ expression is detected in human lung cancer tissues and numerous lung cancer cell lines. Activation of PPARγ through its ligands impedes significantly a variety of tumor progression, including lung cancer. However, systemic activation of PPARγ has been reported to be protumorigenic in some in vitro systems and in vivo models.

Key words:  Lung neoplasms, Peroxisome proliferator-activated receptors, Ligands, Neoplastic processes