Abstract: The occurrence and development of lung cancer are closely related to gene expression and mutations. Recent studies of lung cancer related genes show that the expression of COPS3 gene may play a key role in the lung cancer cell proliferation. Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase fusion gene and epidermal growth factor receptor mutations coexist. GA733 gene is closely related to lung cancer survival. Fibroblast growth factor receptor 1, high mobility protein family, members of the scavenger receptor class 5 and epidermal growth factor receptor provide new ideas for targeted therapy of lung cancer. For the therapy of lung cancer, multiple gene therapy and gene therapy combined with conventional treatment is required.

Key words: Lung neoplasms, Gene expression, Gene therapy