Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (10): 772-775.

Previous Articles     Next Articles

Matrix metalloproteinase-9 in the invasion and metastasis of colorectal cancer

 CHEN  Xing-Zhu, ZHOU  Li-Hong, LI  Qi   

  1. Putuo Hospital and Interventional Oncology Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: LI Qi, E-mail: lzwf@hotmail.com E-mail:lzwf@hotmail.com

Abstract: Matrix metalloproteinases-9(MMP-9) is an important gene in colorectal cancer occurrence and development. MMP-9 can induce cell proliferation, angiogenesis and neoplasm infiltration, and then leads to colorectal cancer invasion and metastasis. MMP-9 can not only play the role individually in colorectal cancer invasion and migration, but also can cooperate with other genes. MMP-9 is a key protease in terminal metastasis of colorectal cancer.

Key words: Matrix metalloproteinases-9, Colorectal neoplasms, Neoplasm invasiveness, Neoplasm metastasis