Journal of International Oncology ›› 2025, Vol. 52 ›› Issue (3): 186-189.doi: 10.3760/cma.j.cn371439-20241224-00029

• Review • Previous Articles     Next Articles

Research progress of the correlation between angiogenesis and osteosarcoma

Pu Wenxia1, Deng Zongzhuo1, Wang Peixin2, Wang Qiulan1()   

  1. 1First School of Clinical Medical,Gansu University of Chinese Medicine,Lanzhou 730000,China
    2Trauma Center,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China
  • Received:2024-12-24 Revised:2025-01-29 Online:2025-03-08 Published:2025-04-02
  • Contact: Wang Qiulan,Email:qiulwang@163.com
  • Supported by:
    Lanzhou Science and Technology Program(2023-2-51)

Abstract:

Osteosarcoma is a kind of mesenchymal tissue tumor,which is highly invasive and metastatic. Pro-angiogenic factors and vascular endothelial cells play key roles in the angiogenesis and metastasis of osteosarcoma,and the interaction between vascular endothelial cells and osteosarcoma cells can affect the growth and metastasis of osteosarcoma. Anti-vascular therapeutics agents for osteosarcoma,including monoclonal antibodies,tyrosine kinase inhibitors and traditional Chinese medicines,can inhibit the progression of osteosarcoma. An in-depth study of the correlation between osteosarcoma and angiogenesis can provide new ideas for the study of vascularization of osteosarcoma and anti-vascular treatment of osteosarcoma.

Key words: Osteosarcoma, Angiogenesis inducing agents, Endothelial cells