国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 602-604.doi: 10.3760/cma.j.issn.1673422X.2015.08.011

• 综述 • 上一篇    下一篇

miR200c在肿瘤诊断、转移与耐药中的作用

李明,邓芳   

  1. 230031  合肥，安徽省肿瘤医院检验科
  • 出版日期:2015-08-08 发布日期:2015-06-29
  • 通讯作者: 邓芳， Email: dengfanger@sina.com E-mail:dengfanger@sina.com
  • 基金资助:

    安徽省自然科学基金（1308085QH144）

Roles of miR200c in tumor diagnosis, metastasis and chemoresistance

LI  Ming, DENG  Fang   

  1. Department of Clinical Laboratory, Anhui Provincial Cancer Hospital, Hefei 230031, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Deng Fang E-mail:dengfanger@sina.com

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摘要： miR200c是miR200家族成员之一，在肿瘤诊断、转移和耐药方面有重要作用。研究表明，miR200c可作为肿瘤筛查的分子标志物和预后判断的指标，能够抑制上皮间质转化和肿瘤侵袭转移，提高肿瘤细胞对抗肿瘤药物的敏感性，但其作用机制尚不明确。miR200c及其调控通路中一些因子的研究，有利于促进其在临床诊疗中的应用。

关键词: 微RNAs, 肿瘤, 上皮间质转化

Abstract: miR200c is a member of miR200 family, and it plays an important role in tumor diagnosis, metastasis and chemoresistance. miR200c is identified as a molecular marker and prognostic indicator in cancer screening. It can inhibit epithelialmesenchymal transition, tumor invasion and metastasis, and increase the chemosensitivity of tumor cells, but the relevant mechanism is still not fully clear. The studies of miR200c and some factors in regulatory pathway are beneficial to promote its applications in clinical diagnosis.

Key words: MicroRNAs, Neoplasms, Epithelialmesenchymal transition