国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 599-601.doi: 10.3760/cma.j.issn.1673422X.2015.08.010

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长非编码RNA在肿瘤上皮间质转化中的研究进展

赵义,张行行,徐岷   

  1. 212000 镇江,江苏大学附属医院消化内科
  • 出版日期:2015-08-08 发布日期:2015-06-29
  • 通讯作者: 徐岷,Email: peterxu1974@163.com E-mail:peterxu1974@163.com
  • 基金资助:

    江苏省卫生厅医学科研课题(H201434);镇江市社会发展科技支撑计划(SH2014024)

Research progress of long noncoding RNA in tumor epithelialmesenchymal transition

ZHAO  Yi, ZHANG  Xing-Xing, XU  Min   

  1. Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Xu Min E-mail:peterxu1974@163.com

摘要: 长非编码RNA(lncRNA)是一类长度大于200个核苷酸的RNA分子,本身不具有编码蛋白质的功能。越来越多的证据表明多种lncRNA如HOTAIR、MALAT1、H19和BANCR等可通过诱导上皮间质转化促进肿瘤的转移。

关键词: 肿瘤转移, 上皮间质转化, 长非编码RNA

Abstract: Long noncoding RNA (lncRNA) is a kind of RNA molecule which is longer than 200 nucleotides and has no capacity of coding proteins. Accumulating evidences have indicated that several lncRNAs, such as HOTAIR, MALAT1, H19 and BANCR may promote tumor metastasis by inducing epithelialmesenchymal transition.

Key words: Neoplasm metastasis, Epithelialmesenchymal transition, Long noncoding RNA