国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (10): 775-778.doi: １０．３７６０／ｃｍａ．ｊ．ｉｓｓｎ．１６７３４２２Ｘ．２０１４．１０．０１７

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胃泌素与微小 ＲＮＡ在促大肠癌细胞增殖中的 关系

杨光,茆家定   

  1. ２４１０００芜湖，皖南医学院弋矶山医院胃肠二科
  • 出版日期:2014-10-29 发布日期:2014-10-11
  • 通讯作者: 茆家定，Ｅｍａｉｌ：ｍａｏｊｉａｄｉｎｇ０２０５＠ｓｉｎａ．ｃｏｍ E-mail:ｍａｏｊｉａｄｉｎｇ０２０５＠ｓｉｎａ．ｃｏｍ
  • 基金资助:

    安徽省自然科学基金（１４０８０８５ＭＨ１４８）

Relationship between gastrin and miRNA in promoting colorectal cancer cell proliferation

 YANG  Guang, MAO  Jia-Ding   

  1. Second Department of Gastrointestinal Surgery, Yijishan Hospital, Wannan Medical College, Wuhu 241000, China
  • Online:2014-10-29 Published:2014-10-11
  • Contact: ＭａｏＪｉａｄｉｎｇ E-mail:ｍａｏｊｉａｄｉｎｇ０２０５＠ｓｉｎａ．ｃｏｍ

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摘要： 研究证实异常表达的胃泌素与其受体结合后可激活相应的信号转导通路，促进大肠癌细 胞增殖、抑制凋亡，而这一过程也与微小 ＲＮＡ（ｍｉＲＮＡ）的表达失调相关。研究表明，ｍｉＲＮＡ在大肠癌中 的调控机制与胃泌素促大肠癌细胞增殖的信号通路存在多个交叉点，因此可能存在一条“胃泌素 ｍｉＲＮＡ靶基因”信号转导通路。若能对该通路加以了解并对相关因素施以控制，将会为大肠癌的基因 靶向治疗开辟一条新的途径。

关键词: 　胃泌素类, 微 ＲＮＡｓ, 结直肠肿瘤

Abstract: It has been demonstrated that the combination of abnomal expression of gastrin with its receptor can promote cell proliferation and inhibit apoptosis in colorectal neoplasms via signal transduction pathways, which is related with the abnormal expression of miRNA. Researches show that there are multiple intersections between the molecule mechanisms of miRNA and the signaling pathway of gastrin in promoting colorectal cancer cell proliferation. It may exist a "gastrinmiRNAtarget gene" signaling transduction pathway. Knowing the mechanism of the signaling pathway and controlling the related factors will open another avenue for the gene targeted therapy of colorectal neoplasms.

Key words: Ｇａｓｔｒｉｎｓ, ＭｉｃｒｏＲＮＡｓ, Ｃｏｌｏｒｅｃｔａｌｎｅｏｐｌａｓｍｓ