国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 401-404.

• 论著 •    下一篇

微小RNA与肿瘤信号转导通路

叶振南, 徐善水, 方兴根   

  1. 241000 芜湖，皖南医学院附属弋矶山医院神经外科
  • 出版日期:2014-06-08 发布日期:2014-05-08
  • 通讯作者: 徐善水，E-mail: wyswxss66@126.com E-mail:wyswxss66@126.com

MicroRNA and cancerassociated signal transduction pathways

Ye Zhennan, Xu Shanshui, Fang Xinggen.   

  1. Department of Neurosurgery, Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241000, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Xu Shanshui E-mail:wyswxss66@126.com

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摘要： 微小RNA(miRNA)与肿瘤的发生发展密切相关，可通过调控其靶基因参与的多个信号转导通路，如表皮生长因子受体信号转导通路、磷脂酰肌醇3羟激酶蛋白激酶B信号转导通路和Ras信号转导通路等，发挥致癌基因或抑癌基因的作用，在肿瘤治疗中具有广阔的应用前景。

关键词: 微RNAs, 肿瘤, 信号传导

Abstract: MicroRNA (miRNA), which is closely related to the occurrence and development of tumors, may act as oncogenes or tumor suppressor genes by regulating target genesrelated signal transduction pathways, such as epidermal growth factor receptor pathway, phosphatidylinositol 3kinaseprotein kinase B pathway and Ras signal transduction pathway. It is believed that miRNAs have broad application prospects in the treatment of tumors.

Key words: MicroRNAs, Neoplasms, Signal transduction