国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 405-407.

• 综述 • 上一篇    下一篇

微小RNA与胶质瘤干细胞放化疗敏感性

陈嘉荣,孙权权,张天,路艳蒙,袁亚维   

  1. 510515广州，南方医科大学南方医院放疗科（陈嘉荣、孙权权、张天、袁亚维）；南方医科大学电镜室（路艳蒙）
  • 出版日期:2014-06-08 发布日期:2014-05-08
  • 基金资助:

    高等学校博士学科点专项科研基金（20114433110015）

Effect of miRNA on radiosensitivity and chemosensitivity in glioma stem cells

 CHEN  Jia-Rong, SUN  Quan-Quan, ZHANG  Tian, LU  Yan-Meng, YUAN  Ya-Wei   

  1. *Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Yuan Yawei E-mail:yuanyw66@aliyun.com

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摘要： 微小RNA（miRNA）的表达与胶质瘤干细胞对放疗及化疗的敏感程度密切相关。许多研究发现，调节单一miRNA能起到提高胶质瘤干细胞的放化疗敏感性、增加细胞凋亡、多方面综合抑制胶质瘤干细胞生长的效果。胶质瘤的治疗策略有望以miRNA为靶点，通过调节miRNA在细胞中的表达，从而达到提高胶质瘤干细胞放化疗敏感性的目的。

关键词: 微RNAs, 神经胶质瘤, 肿瘤干细胞, 放射疗法, 药物疗法

Abstract: The expression of microRNA (miRNA) is closely related to radiochemosensitivity in glioma stem cells (GSCs). Moreover, the growth of glioma stem cells could be inhibited comprehensively by increasing radiochemosensitivity and apoptosis, simultaneously with the regulation of a single miRNA, which has been confirmed by some researches. Thereby microRNA is prospective for the adoption  as a specific agent in targeted therapy of glioma, so as to increase the radiochemosensitivity in glioma stem cells.

Key words: MicroRNAs, Glioma, Neoplastic stem cells, Radiotherapy, Drug therapy