肠道菌群与放射性肠炎的相互作用及研究进展

doi:10.3760/cma.j.cn371439-20230208-00048

摘要/Abstract

摘要：

放疗是腹部及盆腔肿瘤的重要治疗方法，但其不良反应放射性肠炎的发生率较高。腹部及盆腔放疗可诱导肠道隐窝细胞凋亡、破坏肠道屏障、改变肠道菌群组成，肠道菌群失调可加重放射性肠炎。粪便菌群移植及使用益生菌、益生元、抗生素等可调节肠道菌群，是预防和治疗放射性肠炎的有效方法。

关键词: 胃肠道微生物组, 肠炎, 放射疗法

Abstract:

Radiotherapy is an important treatment for abdominal and pelvic tumors， but it has a high incidence of the adverse reaction radiation enteritis. Abdominal and pelvic radiotherapy can induce apoptosis of intestinal crypt cells， destroy the intestinal barrier and change the composition of gut microbiota. Dysbiosis of gut microbiota can aggravate radiation enteritis. Fecal flora transplantation， as well as the use of probiotics， prebiotics and antibiotics can regulate gut microbiota， which is an effective method to prevent and treat radiation enteritis.

Key words: Gastrointestinal microbiome, Enteritis, Radiotherapy

石小琪, 汪红艳. 肠道菌群与放射性肠炎的相互作用及研究进展[J]. 国际肿瘤学杂志, 2023, 50(4): 244-247.

Shi Xaioqi, Wang Hongyan. Research progress on the interaction between gut microbiota and radiation enteritis[J]. Journal of International Oncology, 2023, 50(4): 244-247.

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