国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (11): 811-814.doi: 10.3760/cma.j.issn.1673422X.2013.11.003

• 综述 • 上一篇    下一篇

神经酰胺介导的凋亡效应在肿瘤治疗中的作用

王倩, 谢平   

  1. 南京医科大学附属无锡人民医院中心实验室
  • 出版日期:2013-11-08 发布日期:2013-10-15
  • 通讯作者: 谢平，E-mail：xieping1115@163.com E-mail:xieping1115@163.com

Effects of ceramideinduced apoptosis on oncotherapy

WANG  Qian, XIE  Ping   

  1. Central Laboratory, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China
  • Online:2013-11-08 Published:2013-10-15
  • Contact: XIE Ping, E-mail：xieping1115@163.com E-mail:xieping1115@163.com

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摘要： 神经酰胺(Cer)作为鞘脂类代谢的中心分子，除构成细胞膜结构外，广泛参与细胞生长、分化、衰老、死亡等生理过程，是一类重要的生物效应分子。Cer可通过多种信号通路显著抑制细胞增殖和促进细胞凋亡，以Cer代谢为基础上调其表达的化学制剂抗肿瘤效应在诸多实验研究中得以证实，部分研究成果也已应用于抗肿瘤治疗临床试验。

关键词: 神经酰胺, 细胞凋亡, 肿瘤, 治疗

Abstract: Ceramide (Cer), as the center molecular of sphingolipids metabolism, functions as a bioactive mediator of different cellular processes, such as cell growth, differentiation, senescence and apoptosis, besides being structural component of cellular membrane. It can inhibit cell proliferation and promote cell apoptosis via multiple signal pathawys. Chemicals anticancer properties based on Cer metabolism that upregulate its level are confirmed in plenty of experimental researches, and parts of research productions are applied in anticancer clinic experiments.

Key words: font-family: 'Calibri','sans-serif', mso-bidi-font-size: 11.0pt, mso-ascii-theme-font: minor-latin, mso-fareast-theme-font: minor-fareast, mso-hansi-theme-font: minor-latin, mso-bidi-font-family: 'Times New Roman', mso-bidi-theme-font: minor-bidi, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体">Ceramides, Apoptosis, Neoplasms, Therapy