基因的表达调控及其与肿瘤的关系

doi:10.3760/cma.j.issn.1673422X.2013.11.002

摘要/Abstract

摘要： Bnip3基因属于Bcl-2基因家族BH3-only亚家族，是一种线粒体促凋亡基因，是缺氧诱导因子（HIF）的下游应答基因之一。在缺氧条件下，Bnip3可诱导细胞发生凋亡或自噬，目前研究发现Bnip3与多种肿瘤发生发展及治疗密切相关, 针对Bnip3基因的分子靶向治疗与放化疗联合，在肿瘤治疗上有较好的应用前景。

关键词: 基因表达调控, 肿瘤, Bnip3基因

Abstract: Bnip3, a kind of mitochondrion apoptosis gene, belongs to the Bcl2 gene family and BH3only subfamily. It is one of the downstream response factors of hypoxia inducible factor (HIF). Bnip3 can induce cell apoptosis and autophagy under the oxygen deficit condition. Many studies show that Bnip3 is closely related to the occurrence, development and treatment of tumors. Molecular targeting treatment aimed at Bnip3 combined with chemoradiotherapy has preferable application foreground in tumor therapy.

Key words: Gene expression regulation, Neoplasms, Bnip3 gene

王燕, 李志平. 基因的表达调控及其与肿瘤的关系[J]. 国际肿瘤学杂志, 2013, 40(11): 807-810.

WANG Yan, LI Zhi-Ping. Expression regulation of Bnip3 and its relationship with tumors[J]. Journal of International Oncology, 2013, 40(11): 807-810.

参考文献

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