国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 662-665.

• 综述 • 上一篇    下一篇

鼻咽癌相关基因研究进展

程红蕾, 王若雨   

  1. 116000大连大学附属中山医院肿瘤科

  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 王若雨,E-mail: wry1963@sohu.com E-mail:wry1963@sohu.com

Reserch progress of nasopharyngeal carcinoma related gene

CHENG  Hong-Lei, WANG  Ruo-Yu   

  1. Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian116000, China

  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: WANG Ruo-yu, E-mail: wry1963@sohu.com E-mail:wry1963@sohu.com

摘要: 鼻咽癌的发生是一个多基因参与、多步骤的复杂过程,其中抑癌基因失活和癌基因活化是其发生的重要机制。与鼻咽癌有关的癌基因有Bcl-2、HGF、COX-2、LMP-1,抑癌基因有P53、P16、Nm23-H1、PTEN。随着基因研究的深入,除上述基因外,鼻咽癌还与PECAM-1、MMP-9、RECK等基因有关。这些基因在鼻咽癌的发生、发展过程中有重要作用并有可能成为鼻咽癌治疗的新靶点。

关键词: 鼻咽肿瘤, 基因

Abstract: The occurrence of nasopharyngeal carcinoma is a multi-gene, multi-step process. Among them, oncogene activation and antioncogene inactivation is the important mechanism. The related oncogenes of nasopharyngeal carcinoma contain Bcl-2, HGF, COX-2 and LMP-1. The related antioncogenes of nasopharyngeal carcinoma contain P53, P16, NM23-H1 and PTEN. With the deepening research on genes, studies also find that nasopharyngeal carcinoma is related to PECAM-1, MMP-9 and RECK. These genes play important roles in the occurrence and development of nasopharyngeal carcinoma, which may become new targets for the treatment of nasopharyngeal carcinoma.

Key words: Nasopharyngeal neoplasms, Genes