CeRNA网络介导恶性肿瘤表型调控的机制研究

doi:10.3760/cma.j.cn371439-20201122-00105

摘要/Abstract

摘要：

竞争性内源RNA(CeRNA)是纵横交错的调控网络,该网络可介导恶性肿瘤细胞表型,包括增殖和抑制、自噬、无限生长、诱导血管生成和血管生成拟态、免疫逃逸等。了解CeRNA介导恶性肿瘤表型调控及其功能,有望为恶性肿瘤提供新的诊断标志物和治疗靶点。

关键词: 基因表达调控,肿瘤, RNA,长链非编码, 表型, CeRNA

Abstract:

Competing endogenous RNAs (CeRNAs) are crisscrossing regulatory networks. CeRNAs networks can mediate malignant tumor cell phenotypes, including proliferation and inhibition, autophagy, infinite growth, induction of angiogenesis and angiogenic mimicosis, immune escape, etc.. It is expected to provide new diagnostic markers and therapeutic targets for malignant tumors to master the regulation and function of CeRNAs mediated phenotype in malignant tumors.

Key words: Gene expression regulation, neoplastic, RNA, long noncoding, Phenotype, CeRNA

张静, 黄守国, 夏鹰. CeRNA网络介导恶性肿瘤表型调控的机制研究[J]. 国际肿瘤学杂志, 2021, 48(9): 544-548.

Zhang Jing, Huang Shouguo, Xia Ying. Mechanism study of CeRNA regulatory network mediating malignant tumor phenotype[J]. Journal of International Oncology, 2021, 48(9): 544-548.

参考文献 41

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[38]	Wang CJ, Zhu CC, Xu J, et al. The lncRNA UCA1 promotes proli-feration, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs[J]. Mol Cancer, 2019, 18(1):115. DOI: 10.1186/s12943-019-1032-0. doi: 10.1186/s12943-019-1032-0
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