外泌体-环状RNA在肿瘤诊治中的临床意义

doi:10.3760/cma.j.cn371439-20210206-00106

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (9): 549-552.doi: 10.3760/cma.j.cn371439-20210206-00106

外泌体-环状RNA在肿瘤诊治中的临床意义

张琬琛¹, 徐加杰², 张李卓¹, 葛明华²()

¹浙江中医药大学第二临床医学院,杭州 310053
²浙江省人民医院头颈外科浙江省内分泌腺体疾病诊治研究重点实验室,杭州 310014

收稿日期:2021-02-06 修回日期:2021-03-15 出版日期:2021-09-08 发布日期:2021-09-22
通讯作者: 葛明华 E-mail:gemingh@163.com
基金资助:
国家自然科学基金(81802674);浙江省自然科学基金(LY21H160049);浙江省医药卫生科学研究基金(2021419088);浙江省中医药优秀青年人才基金(2018ZQ010)

Clinical significance of exosomal-circRNA in tumor diagnosis and treatment

Zhang Wanchen¹, Xu Jiajie², Zhang Lizhuo¹, Ge Minghua²()

¹Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
²Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province, Hangzhou 310014, China

Received:2021-02-06 Revised:2021-03-15 Online:2021-09-08 Published:2021-09-22
Contact: Ge Minghua E-mail:gemingh@163.com
Supported by:
National Natural Science Foundation of China(81802674);Natural Science Foundation of Zhejiang Province of China(LY21H160049);Medical and Health Science Research Foundation of Zhejiang Province of China(2021419088);Zhejiang Provincial Traditional Chinese Medicine Outstanding Young Talents Fund Project(2018ZQ010)

摘要/Abstract

摘要：

肿瘤来源的外泌体中存在丰富且稳定的环状RNA,其在肿瘤的发生发展中发挥重要作用。外泌体-环状RNA可作为肿瘤诊断和预后的标志物,并且在不同的肿瘤中具有调节肿瘤免疫反应、调控肿瘤进展和介导肿瘤耐药等作用。探索和应用外泌体-环状RNA潜在的价值将为肿瘤的诊治提供新的选择。

关键词: 外泌体, 肿瘤, 环状RNA

Abstract:

There are abundant and stable circular RNAs in tumor-derived exosomes, which play an important role in the occurrences and developments of tumors. Exosome-circRNAs can be used as the marker of tumors diagnosis and prognosis, and have different roles in regulating tumors immune responses, regulating tumors progressions and mediating tumors drug resistances in different tumors. Exploring and applying the potential value of exosome-circRNAs will provide a new choice for the diagnosis and treatment of tumors.

Key words: Exosomes, Neoplasms, Circular RNA

张琬琛, 徐加杰, 张李卓, 葛明华. 外泌体-环状RNA在肿瘤诊治中的临床意义[J]. 国际肿瘤学杂志, 2021, 48(9): 549-552.

Zhang Wanchen, Xu Jiajie, Zhang Lizhuo, Ge Minghua. Clinical significance of exosomal-circRNA in tumor diagnosis and treatment[J]. Journal of International Oncology, 2021, 48(9): 549-552.

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外泌体-环状RNA在肿瘤诊治中的临床意义

Clinical significance of exosomal-circRNA in tumor diagnosis and treatment

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