HER2靶向药物及其联合治疗方案在胃及食管胃结合部腺癌治疗中的研究进展

doi:10.3760/cma.j.cn371439-20230911-00141

国际肿瘤学杂志 ›› 2023, Vol. 50 ›› Issue (12): 751-757.doi: 10.3760/cma.j.cn371439-20230911-00141

HER2靶向药物及其联合治疗方案在胃及食管胃结合部腺癌治疗中的研究进展

邓莉莉¹^,², 段星宇³, 李保中⁴()

¹河南科技大学临床医学系，洛阳 471000
²河南省安阳市肿瘤医院肿瘤内科，安阳 455000
³新乡医学院附属郑州市第一人民医院骨科，郑州 450000
⁴河南省安阳市肿瘤医院外科，安阳 455000

收稿日期:2023-09-11 修回日期:2023-10-16 出版日期:2023-12-08 发布日期:2024-01-16
通讯作者: 李保中 E-mail:libaozhong99@126.com
基金资助:
安阳市重大科技专项(2022A02SF010)

Advances of anti-HER2 targeted drugs and combined therapeutic regimens for gastric and esophagogastic adenocarcinoma

Deng Lili¹^,², Duan Xingyu³, Li Baozhong⁴()

¹Department of Clinical Medicine， Henan University of Science and Technology， Luoyang 471000， China
²Department of Oncology， Anyang Tumor Hospital of Henan Province， Anyang 455000， China
³Department of Orthopedics， First People's Hospital of Zhengzhou Affiliated to Xinxiang Medical College， Zhengzhou 450000， China
⁴Department of Surgery， Anyang Tumor Hospital of Henan Province， Anyang 455000， China

Received:2023-09-11 Revised:2023-10-16 Online:2023-12-08 Published:2024-01-16
Contact: Li Baozhong E-mail:libaozhong99@126.com
Supported by:
Major Science and Technology Project in Anyang(2022A02SF010)

摘要/Abstract

摘要：

人表皮生长因子受体2（HER2）过表达或扩增胃及食管胃结合部腺癌可从抗HER2治疗中显著获益。目前，除曲妥珠单抗、帕妥珠单抗等人源化单克隆抗体外，多种针对HER2的抗体偶联药（恩美曲妥珠单抗、维迪西妥单抗、德喜曲妥珠单抗、ARX788）及酪氨酸激酶抑制剂（拉帕替尼、阿法替尼、吡咯替尼），可作为单一疗法或联合疗法应用于晚期胃及食管胃结合部腺癌的治疗，已在临床研究中显示出良好疗效，改善了患者预后及生命质量。进一步研究新型HER2靶向药物及联合治疗方案在临床治疗中的疗效与安全性，有望为HER2阳性晚期胃及食管胃结合部腺癌患者的治疗提供更有效的策略。

关键词: 胃肿瘤, 腺癌, 食管胃接合处, 基因，erbB-2, 分子靶向治疗

Abstract:

Patients with human epidermal growth factor receptor 2 （HER2） overexpression or amplification in gastric and esophagogastic adenocarcinoma can significantly benefit from anti-HER2 therapies. Presently， various humanized monoclonal antibodies such as trastuzumab and pertuzumab， alongside diverse anti-HER2 antibody drug conjugates （trastuzumab emtansine， disitamab vedotin， trastuzumab deruxtecan， ARX788）， and tyrosine kinase inhibitors （lapatinib， afatinib， pyrotinib）， are employed either as monotherapy or in combination settings for advanced gastric and esophagogastic adenocarcinoma. These therapeutic modalities have demonstrated promising clinical efficacy in clinical trials， thereby ameliorating patients' prognosis and enhancing life quality. Further exploration on the efficacy and safety of novel HER2-targeted agents and combined therapeutic regimens in clinical practice holds the promise of furnishing more efficacious strategies for treating HER2-positive advanced gastric and esophagogastic adenocarcinoma.

Key words: Stomach neoplasms, Adenocarcinoma, Esophagogastric junction, Genes， erbB-2, Molecular targeted therapy

邓莉莉, 段星宇, 李保中. HER2靶向药物及其联合治疗方案在胃及食管胃结合部腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(12): 751-757.

Deng Lili, Duan Xingyu, Li Baozhong. Advances of anti-HER2 targeted drugs and combined therapeutic regimens for gastric and esophagogastic adenocarcinoma[J]. Journal of International Oncology, 2023, 50(12): 751-757.

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HER2靶向药物及其联合治疗方案在胃及食管胃结合部腺癌治疗中的研究进展

Advances of anti-HER2 targeted drugs and combined therapeutic regimens for gastric and esophagogastic adenocarcinoma

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