中晚期肝细胞癌介入及系统治疗的现状与研究进展

doi:10.3760/cma.j.cn371439-20230805-00142

摘要/Abstract

摘要：

肝细胞癌（HCC）是我国发病率及死亡率位居前列的常见恶性肿瘤，大部分患者就诊时已处于中晚期。介入治疗是HCC局部治疗的最主要手段，CalliSpheres载药微球作为一种新型介入材料，比传统经导管肝动脉化疗栓塞术的碘油具有明显优势，肝动脉灌注化疗对肿瘤有更高的缓解率及转化成功率；目前一系列靶向药物如仑伐替尼、多纳非尼、阿帕替尼，相继获批用于晚期HCC的治疗；免疫检查点抑制剂在晚期HCC治疗中取得了突破性进展，各种新药不断涌现，各种治疗药物组合的临床研究也不断进步。探讨近期介入、靶向及免疫治疗在中晚期HCC治疗的最新应用及临床研究进展，以期为HCC治疗提供决策参考。

关键词: 癌，肝细胞, 分子靶向治疗, 免疫检查点抑制剂, 介入治疗

Abstract:

Hepatocellular carcinoma （HCC） is a common malignant tumor with high incidence and mortality rates in China. Most patients are diagnosed at an advanced stage when seeking medical treatment. Interventional therapy is the main local treatment for HCC. As a new interventional material， CalliSpheres drug-eluting microspheres have more advantages than iodipin in traditional transcatheter chemoembolization， and hepatic artery infusion chemotherapy has higher rates of remission and translation. A series of targeted drugs， such as lenvatinib， donafinib， and apatinib have been approved for application in the treatment of advanced HCC. Immune checkpoint inhibitors have made breakthroughs in the treatment of advanced HCC. Various new drugs are emerging， with clinical studies on various combinations of different therapeutic drugs being gaining new findings. This article aims to discuss the recent applications and clinical research progress of interventional therapy， targeted therapy and immunotherapy in the treatment of advanced HCC so as to provide a reference for the decision-making of HCC.

Key words: Carcinoma， hepatocellular, Molecular targeted therapy, Immune checkpoint inhibitors, Interventionaltherapy

刘绍平, 罗汉传, 林书瀚, 罗家辉. 中晚期肝细胞癌介入及系统治疗的现状与研究进展[J]. 国际肿瘤学杂志, 2023, 50(12): 758-762.

Liu Shaoping, Luo Hanchuan, Lin Shuhan, Luo Jiahui. Current status and research progress of interventional and systemic therapy for advanced hepatocellular carcinoma[J]. Journal of International Oncology, 2023, 50(12): 758-762.

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