鼻咽癌免疫治疗的临床研究进展

doi:10.3760/cma.j.cn371439-20230120-00060

摘要/Abstract

摘要：

免疫治疗主要是利用机体免疫系统的各效应单元克服肿瘤的免疫逃逸或适应性免疫抵抗，精准识别并清除肿瘤细胞，使免疫系统的功能正常化或增强；其主要包括细胞因子治疗、抑制免疫检查点治疗、过继细胞免疫治疗、肿瘤疫苗和抗体靶向治疗等。鼻咽癌的免疫特征使患者可能适合免疫治疗或与放化疗联合治疗。近年来，PD-1抑制剂单独治疗及其与化疗联合治疗在复发/转移的鼻咽癌治疗中表现出良好的抗肿瘤活性及安全性，将免疫检查点抑制剂纳入鼻咽癌的治疗模式已成为临床研究的热点。

关键词: 鼻咽肿瘤, 免疫疗法, 免疫检查点抑制剂, 免疫疗法，过继

Abstract:

Immunotherapy mainly uses the effector units of the body's immune system to overcome the immune escape or adaptive immune resistance of tumors， accurately identify and remove tumor cells， and normalize or enhance the function of the immune system， which mainly includes cytokine therapy， immune checkpoint inhibition therapy， adoptive cell immunotherapy， tumor vaccine and antibody targeted therapy. The immune characteristics of nasopharyngeal carcinoma make the patients potentially suitable for immunotherapy or combined therapy with radiotherapy and chemotherapy. In recent years， PD-1 inhibitors alone and in combination with chemotherapy have shown good anti-tumor activity and safety in the treatment of recurrent/metastatic nasopharyngeal carcinoma. The incorporation of immune checkpoint inhibitors into the treatment paradigms of nasopharyngeal carcinoma has become a clinical research hot spot.

Key words: Nasopharyngeal neoplasms, Immunotherapy, Immune checkpoint inhibitors, Immunotherapy， adoptive

顾安琴, 龙金华, 金风. 鼻咽癌免疫治疗的临床研究进展[J]. 国际肿瘤学杂志, 2023, 50(5): 299-303.

Gu Anqin, Long Jinhua, Jin Feng. Clinical research progress of immunotherapy for nasopharyngeal carcinoma[J]. Journal of International Oncology, 2023, 50(5): 299-303.

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