国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (7): 541-544.

• 综述 • 上一篇    下一篇

Numb在肿瘤中的作用

王超,张楚瑶,冯炜炜   

  1. 上海，复旦大学附属妇产科医院妇产科
  • 出版日期:2012-08-06 发布日期:2012-08-06
  • 通讯作者: 冯炜炜，E-mail: jingsakura@gmail.com E-mail:jingsakura@gmail.com
  • 基金资助:

    国家自然科学基金资助项目（81001149）；上海市卫生局新优青项目人才计划 (XYQ2011062)

Role of Numb in tumors

WANG  Chao, ZHANG  Chu-Yao, FENG  Wei-Wei   

  1. Department of Gynecology and Obstetrics, Obstetrics ＆ Gynecology Hospital of Fudan University, Shanghai 200011, China
  • Online:2012-08-06 Published:2012-08-06
  • Contact: FENG Wei-wei, E-mail: jingsakura@gmail.com E-mail:jingsakura@gmail.com

PDF

1866

被引次数

6

摘要： Numb是生物体内重要的细胞命运决定因子之一, 不仅对神经系统的发育起着关键性的作用，与肿瘤的发生也密切相关。Numb通过影响细胞分裂方式、细胞极性、上皮间质转化等过程，通过对Notch、p53、Hg等重要信号通路的调节影响肿瘤的形成、浸润与转移。Numb表达水平与肿瘤疾病的恶性程度及预后密切相关，探索Numb在肿瘤中的作用对今后将Numb作为肿瘤治疗的新靶点具有重要意义。

关键词: 肿瘤, 细胞分裂, Numb蛋白

Abstract: Numb, one of the important cell fate determinants, plays a key role in regulation of nerve system development, and it is closely related to the occurrence of tumors. It is proven that Numb is implicated in the processes of occurrence, invasion and metastasis of tumors through regulating the way of cell division, cell polarity, epithelialmesenchymal transitions and several signal pathways, e.g., Notch, Hh, p53. The expression levels of Numb in cells are related to the malignant degree and prognosis of tumors. It is vital to explore the role of Numb in tumors for treating tumors at the standpoint of Numb. 

Key words: Neoplasms, Cell Division, Numb protein