国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (7): 538-540.

• 综述 • 上一篇    下一篇

小干扰RNA在胃肠道肿瘤中的研究进展

居峰,左君波,夏加增   

  1. 南京医科大学附属无锡第二医院普外科
  • 出版日期:2012-08-06 发布日期:2012-08-06
  • 通讯作者: 夏加增，E-mail:jzxia_99@yahoo.com E-mail:jzxia_99@yahoo.com

Small interfering RNA in gastrointestinal cancer

JU  Feng, ZUO  Jun-Bo, XIA  Jia-Zeng   

  1. Department of General Surgery, Wuxi Second Hospital, Nanjing Medical University, Wuxi 214002, China
  • Online:2012-08-06 Published:2012-08-06
  • Contact: XIA jia-zeng, E-mail: jzxia_99@yahoo.com E-mail:jzxia_99@yahoo.com

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摘要： 小干扰RNA（siRNA）是由双链RNA（dsRNA）经Dicer酶加工成的小分子片段。21～25 nt的siRNA作为RNA干扰（RNAi）过程中的关键效应分子，在哺乳动物细胞中能够高特异性、高效性地抑制基因的表达。目前，RNAi被广泛地应用于各种肿瘤的研究，在胃肠道肿瘤方面，针对肿瘤的发生发展、转移以及治疗等方面都有许多积极的研究探索。

关键词: RNA, 小分子干扰, RNA干扰, 胃肠肿瘤

Abstract: SiRNA comes from doublestranded RNA, which is processed into a small molecular fragment by Dicer. 2125nt siRNA, as the key effector molecules to the RNAi process, can inhibit gene expression with high specificity and high efficiency in mammalian cells. Currently, RNAi has been widely applied in a variety of cancer. RNAi has many active research explorations of the tumor development, metastasis and treatment in gastrointestinal cancer.

Key words: RNA, small interfering, RNA interference, Gastrointestinal neoplasms