关键词: 恶病质, 诊断, 肿瘤分期, 蛋白酶体

Abstract: Cancer cachexia (CC) caused by cancer is a syndrome with complicated symptoms. Traditional therapies usually give interventions for more nutrition intake at CC late stage and take weight as the outcome marker. Lots of clinical trials demonstrate that the effect is not satisfactory. Recent studies show that the level of NF-κB decreased, termination of the breakdown of myofibrillar proteins, the serum proteins and lean body mass increased and function improvement after targeting proteasome at early stage of CC combined with traditional therapy. 

Key words: Cachexia, Diagnosis, Neoplasm staging, Proteasome