SoxC基因家族在肿瘤发生发展中的作用及其临床意义

doi:10.3760/cma.j.cn371439-20220408-00079

国际肿瘤学杂志 ›› 2022, Vol. 49 ›› Issue (7): 416-419.doi: 10.3760/cma.j.cn371439-20220408-00079

SoxC基因家族在肿瘤发生发展中的作用及其临床意义

张丹丹^1,², 林高忍^1,², 肖倩^1,², 刘英^1,²()

1.川北医学院口腔医学系,南充 637000
2.川北医学院附属医院口腔科,南充 637000

收稿日期:2022-04-08 修回日期:2022-06-10 出版日期:2022-07-08 发布日期:2022-09-19
通讯作者: 刘英 E-mail:xiaoying2266@sina.com
基金资助:
川北医学院2019年国家自然（社会）科学基金预研项目(CBY19-YZ08);2021年度川北医学院附属医院第一批临床研究课题(2021LC010)

Roles of the SoxC family in tumor development and its clinical significance

Zhang Dandan^1,², Lin Gaoren^1,², Xiao Qian^1,², Liu Ying^1,²()

1. Department of Stomatology, North Sichuan Medical College, Nanchong 637000, China
2. Department of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Received:2022-04-08 Revised:2022-06-10 Online:2022-07-08 Published:2022-09-19
Contact: Liu Ying E-mail:xiaoying2266@sina.com
Supported by:
Preresearch Project of the 2019 National Natural （Social） Science Foundation of North Sichuan Medical College(CBY19-YZ08);The First Batch of Clinical Research Project of the Affiliated Hospital of North Sichuan Medical College in 2021(2021LC010)

摘要/Abstract

摘要：

SoxC转录因子组是一类参与基因转录、翻译和表达的重要蛋白质分子,可以通过特异性结合相应靶基因或蛋白调节基因的表达。SoxC基因家族具有独特的分子结构特征,其成员Sox4、Sox11、Sox12分别在多种肿瘤中出现异常表达,可作为不同种肿瘤的诊断及预后标志物。研究SoxC转录因子家族的致病机制及其临床意义,可以增加SoxC作为肿瘤治疗靶点的证据。

关键词: SoxC转录因子类, 肿瘤, 转录因子

Abstract:

SoxC transcription factors are a group of important protein molecules involved in gene transcription, translation and expression, which can regulate gene expression by specifically binding to corresponding target genes or proteins. The SoxC gene family has unique molecular structure features. Its members Sox4, Sox11 and Sox12 are abnormally expressed in a variety of tumors, and can be used as diagnostic and prognostic markers for different tumors. Investigating the pathogenic mechanisms of the SoxC transcription factor family and their clinical significance can increase the evidence for SoxC as a therapeutic target for tumors.

Key words: SoxC transcription factors, Neoplasms, Transcription factors

张丹丹, 林高忍, 肖倩, 刘英. SoxC基因家族在肿瘤发生发展中的作用及其临床意义[J]. 国际肿瘤学杂志, 2022, 49(7): 416-419.

Zhang Dandan, Lin Gaoren, Xiao Qian, Liu Ying. Roles of the SoxC family in tumor development and its clinical significance[J]. Journal of International Oncology, 2022, 49(7): 416-419.

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SoxC基因家族在肿瘤发生发展中的作用及其临床意义

Roles of the SoxC family in tumor development and its clinical significance

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