CDCA8与肿瘤发生发展及干细胞干性维持的关系

doi:10.3760/cma.j.cn371439-20201012-00043

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (4): 216-219.doi: 10.3760/cma.j.cn371439-20201012-00043

CDCA8与肿瘤发生发展及干细胞干性维持的关系

魏永健¹, 胡进静², 李汛^1,^2,³()

¹兰州大学第一临床医学院 730000
²甘肃省生物治疗与再生医学重点实验室,兰州730000
³兰州大学第一医院普外科兰州大学医学院肿瘤防治中心甘肃省肝胆胰外科研究所,兰州 730000

收稿日期:2020-10-12 修回日期:2020-12-25 出版日期:2021-04-08 发布日期:2021-06-18
通讯作者: 李汛 E-mail:lxdr21@126.com
基金资助:
国家自然科学基金(31570509);甘肃省科技计划(18JR2TA018);甘肃省科技重大专项(1602FKDA001);甘肃省高等学校创新能力提升项目(2019B-003);兰州大学“中央高校基本科研业务费专项资金”项目(lzujbky-2019-kb21);兰州大学“中央高校基本科研业务费专项资金”项目(lzujbky-2020-kb22)

Relationship between CDCA8 and tumor progression as well as that between CDCA8 and stemness maintenance of stem cells

Wei Yongjian¹, Hu Jinjing², Li Xun^1,^2,³()

¹First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China
²Gansu Provincial Key Laboratory of Biological Therapy and Regenerative Medicine Transformation, Lanzhou 730000, China
³Department of General Surgery, First Hospital of Lanzhou University, Medical College of Lanzhou University Trauma Prevention and Treatment Center, Gansu Provincial Research Institute of Hepato-Pancreato-Biliary Surgery, Lanzhou 730000, China

Received:2020-10-12 Revised:2020-12-25 Online:2021-04-08 Published:2021-06-18
Contact: Li Xun E-mail:lxdr21@126.com
Supported by:
National Natural Science Foundation of China(31570509);Gansu Provincial Science and Technology Plan Project of China(18JR2TA018);Gansu Provincial Major Science and Technology Project of China(1602FKDA001);Gansu Provincial Innovation Capability Improvement Project of Colleges and Universities(2019B-003);"Central Universities Basic Scientific Research Service Fees" of Lanzhou University(lzujbky-2019-kb21);"Central Universities Basic Scientific Research Service Fees" of Lanzhou University(lzujbky-2020-kb22)

摘要/Abstract

摘要：

细胞分裂周期相关基因8(CDCA8)参与细胞分裂周期的准确调控,其表达的改变可影响多种肿瘤的发生发展及患者预后。近年来研究发现,CDCA8可能在肿瘤干细胞的干性维持中起重要作用。探索CDCA8影响肿瘤的相关机制对于肿瘤的诊治具有十分重要的意义。

关键词: 肿瘤, 肿瘤干细胞, 细胞分裂周期相关基因8, 机制

Abstract:

Cell division cycle associated 8 (CDCA8) is involved in the accurate regulation of cell division cycle. The expression change of CDCA8 can affect the progression of many kinds of tumors as well as the prognosis of patients. In recent years, studies have suggested that CDCA8 may play an important role in maintaining the stemness of cancer stem cells. Exploring the mechanism of CDCA8 affecting tumor is of great significance for the diagnosis and treatment of tumors.

Key words: Neoplasms, Neoplastic stem cells, Cell division cycle associated 8, Mechanism

魏永健, 胡进静, 李汛. CDCA8与肿瘤发生发展及干细胞干性维持的关系[J]. 国际肿瘤学杂志, 2021, 48(4): 216-219.

Wei Yongjian, Hu Jinjing, Li Xun. Relationship between CDCA8 and tumor progression as well as that between CDCA8 and stemness maintenance of stem cells[J]. Journal of International Oncology, 2021, 48(4): 216-219.

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CDCA8与肿瘤发生发展及干细胞干性维持的关系

Relationship between CDCA8 and tumor progression as well as that between CDCA8 and stemness maintenance of stem cells

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