肿瘤的分化治疗

doi:10.3760/cma.j.cn371439-20231013-00016

摘要/Abstract

摘要：

肿瘤细胞有去分化、分化阻断和转分化3种表型可塑，靶向肿瘤细胞可塑的分化治疗已经成为新的肿瘤治疗模式。肿瘤分化治疗应用诱导分化、启动分化和调控分化促进肿瘤细胞向成熟细胞定向分化和重建正常表型，从而实现肿瘤治疗的目的。

Abstract:

Cancer phenotypic plasticity includes dedifferentiation，blocked differentiation and trans- differentiation，and differentiation therapy targeting tumor cell plasticity is becoming a new therapeutic model for human cancers. The application of inducing differentiation，initiating differentiation and regulating differentiation in tumor differentiation therapy will promote the directed differentiation of tumor cells into mature cells and the remodeling of phenotypes，thus to achieve the purpose of cancer treatment.

Key words: Neoplasms, Cell differentiation, Drug therapy

岳红云, 张百红. 肿瘤的分化治疗[J]. 国际肿瘤学杂志, 2024, 51(2): 109-113.

Yue Hongyun, Zhang Baihong. Differentiation therapies in human cancers[J]. Journal of International Oncology, 2024, 51(2): 109-113.

图/表 1

参考文献 45

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细胞可塑	作用机制	药物类型	临床试验
诱导分化	表观遗传剂	EZH2抑制剂，HDAC抑制剂	临床前研究^[10⇓-12]
	自噬诱导剂	ULK1抑制剂	临床前研究^[13]
	干性调节剂	SOX2抑制剂，Wnt抑制剂，MEK抑制剂，erastin	临床前研究^[15⇓-17]
启动分化	代谢调节剂	Vorasidenib	Ⅱ期^[20-21]
	转录因子调节剂	SOX10拮抗剂	临床前研究^[25]
	免疫细胞分化剂	抗PD-1/PD-L1抗体	临床应用^[27-28]
调控分化	染色质可塑剂	Exportin1抑制剂，LSD1抑制剂	临床前研究^[33⇓-35]
	血管生成抑制剂	瑞格非尼	临床应用^[36]
	生长信号阻断剂	ZNF117	临床前研究^[38]
	衰老细胞清除剂	抗PD-1/PD-L1抗体	临床应用^[42]