细胞焦亡在白血病中的研究进展

doi:10.3760/cma.j.cn371439-20230715-00131

摘要/Abstract

摘要：

细胞焦亡是由Gasdermin蛋白家族介导的程序性细胞死亡，它不同于凋亡和坏死，过程中伴有大量促炎因子释放。白血病是一类源于造血干细胞的恶性增殖性疾病，其发病及进展与多因素有关。近年来，随着对细胞焦亡机制的深入研究，发现细胞焦亡与白血病的发生发展密切相关。深入研究细胞焦亡在白血病中的作用机制，可为白血病诊断及治疗提供新的思路。

关键词: 细胞焦亡, 白血病, 肿瘤

Abstract:

Pyroptosis is a programmed cell death mediated by the Gasdermin family of proteins，which is different from apoptosis and necrosis and accompanied by the release of a large number of pro-inflammatory factors. Leukemia is a malignant proliferative disease derived from hematopoietic stem cells，the pathogenesis and progression of which are related to many factors. In recent years，with the in-depth study on the mechanism of pyroptosis，it has been found that pyroptosis is closely related to the occurrence and development of leukemia. Further study of the mechanism of pyroptosis in leukemia can provide a new idea for the diagnosis and treatment of leukemia.

Key words: Pyroptosis, Leukemia, Neoplasms

张婷, 贾秀红. 细胞焦亡在白血病中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(11): 696-700.

Zhang Ting, Jia Xiuhong. Research progress of pyroptosis in leukemia[J]. Journal of International Oncology, 2023, 50(11): 696-700.

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