Mfn2在肿瘤中的研究进展

doi:10.3760/cma.j.cn371439-20200212-00008

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (1): 45-47.doi: 10.3760/cma.j.cn371439-20200212-00008

Mfn2在肿瘤中的研究进展

魏梦雨, 马力()

河北医科大学第四医院乳腺中心,石家庄 050011

收稿日期:2020-02-12 修回日期:2020-08-12 出版日期:2021-01-08 发布日期:2021-01-21
通讯作者: 马力 E-mail:mali1021@126.com
基金资助:
河北省自然科学基金(H2015206230)

Research advances of Mfn2 in tumor

Wei Mengyu, Ma Li()

Department of Breast Disease Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

Received:2020-02-12 Revised:2020-08-12 Online:2021-01-08 Published:2021-01-21
Contact: Ma Li E-mail:mali1021@126.com
Supported by:
National Science Foundation of Hebei Province of China(H2015206230)

摘要/Abstract

摘要：

线粒体融合蛋白2(Mfn2)在线粒体融合过程中发挥着重要作用,参与调节线粒体功能和形态学的改变。近年来研究发现,Mfn2在多种恶性肿瘤及其细胞株中具有抑癌作用,包括宫颈癌、肝细胞癌、胰腺癌、乳腺癌和膀胱癌等。Mfn2在恶性肿瘤组织中表达情况的差异,提示其可能在恶性肿瘤细胞增殖、凋亡、侵袭和转移过程中发挥重要作用。Mfn2作为一种肿瘤相关基因,为恶性肿瘤的基因治疗提供了新的思路。

关键词: 肿瘤, Mfn2, 细胞增殖, 细胞凋亡, 细胞侵袭

Abstract:

Mitofusin 2 (Mfn2) plays an important role in the process of mitochondrial fusion, and is involved in regulating mitochondrial function and morphological changes. Studies have found that Mfn2 has a tumor suppressor effect in a variety of malignant tumors and their cell lines, including cervical cancer, hepatocellular cancer, pancreatic cancer, breast cancer, and bladder cancer. The difference in the expression of Mfn2 in malignant tumor tissues suggests that Mfn2 may play an important role in the proliferation, apoptosis, invasion and migration of malignant tumor cells. As a cancer-related gene, Mfn2 provides new ideas for gene therapy of malignant tumors.

Key words: Neoplasms, Mfn2, Cell proliferation, Cell apoptosis, Cell invasion

魏梦雨, 马力. Mfn2在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2021, 48(1): 45-47.

Wei Mengyu, Ma Li. Research advances of Mfn2 in tumor[J]. Journal of International Oncology, 2021, 48(1): 45-47.

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Mfn2在肿瘤中的研究进展

Research advances of Mfn2 in tumor

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