环状RNA与肿瘤耐药的关系

doi:10.3760/cma.j.cn371439-20191031-00006

国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (4): 223-226.doi: 10.3760/cma.j.cn371439-20191031-00006

环状RNA与肿瘤耐药的关系

袁霜, 孙笑, 王丽华()

上海交通大学医学院附属国际和平妇幼保健院妇科肿瘤科 200030

收稿日期:2019-10-31 修回日期:2020-01-03 出版日期:2020-04-08 发布日期:2020-05-26
通讯作者: 王丽华 E-mail:drwanglh0420@163.com
基金资助:
国家自然科学基金(81572547)

Relationship between circular RNA and cancer drug resistance

Yuan Shuang, Sun Xiao, Wang Lihua()

Department of Gynecologic Oncology, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Received:2019-10-31 Revised:2020-01-03 Online:2020-04-08 Published:2020-05-26
Contact: Wang Lihua E-mail:drwanglh0420@163.com
Supported by:
National Natural Science Foundation of China(81572547)

摘要/Abstract

摘要：

环状RNA是非编码RNA家族的成员,可以多种方式参与生物学功能,如细胞增殖、细胞周期、侵袭和转移等。近年来研究发现,环状RNA可以通过海绵吸附微小RNA和RNA结合蛋白参与转录后调控,从而影响肿瘤耐药过程中的DNA修复、凋亡、增殖、细胞转运,以及介导肿瘤耐药的细胞内酶,进而在肿瘤耐药中发挥重要调节作用。研究证实通过干扰环状RNA的表达,可以提高肿瘤对药物的敏感性,提示环状RNA可能为抗肿瘤药物耐药性的研究提供新的靶点。

关键词: 微RNAs, 肿瘤, 抗药性

Abstract:

Circular RNA is a member of the non-coding RNA family and can participate in biological functions in many ways, such as cell proliferation, cell cycle, invasion and metastasis. Recent studies have shown that circular RNA can be involved in post transcriptional regulation by sponge miRNA and RNA binding proteins. Thus, it can affect DNA repair, apoptosis, proliferation, cell transport, and intracellular enzymes those mediate drug resistance, so as to play an important regulatory role in drug resistance. Moreover, it has been confirmed that interfering with the expression of circular RNA can improve the sensitivity of cancer to drugs, suggesting that circular RNA may provide a new target for the study of drug resistance of cancer.

Key words: MicroRNAs, Neoplasms, Drug resistance

袁霜, 孙笑, 王丽华. 环状RNA与肿瘤耐药的关系[J]. 国际肿瘤学杂志, 2020, 47(4): 223-226.

Yuan Shuang, Sun Xiao, Wang Lihua. Relationship between circular RNA and cancer drug resistance[J]. Journal of International Oncology, 2020, 47(4): 223-226.

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环状RNA与肿瘤耐药的关系

Relationship between circular RNA and cancer drug resistance

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