国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (11): 678-681.doi: 10.3760/cma.j.issn.1673-422X.2019.11.007

• 综述 • 上一篇    下一篇

EDIL3在肿瘤中的研究进展

柯彬，李斌，梁寒   

  1. 天津医科大学肿瘤医院胃部肿瘤科 国家肿瘤临床医学研究中心 天津市“肿瘤防治”重点实验室 天津市恶性肿瘤临床医学研究中心300060
  • 出版日期:2019-11-08 发布日期:2019-12-26
  • 通讯作者: 梁寒 E-mail:tj_lianghan@126.com
  • 基金资助:
    肿瘤； 血管生成； 细胞凋亡； 表皮生长因子样重复盘状结构Ⅰ样域蛋白3
    基金项目：国家自然科学基金（81401952）；天津市卫生局科技基金(2014KZ082)

Research advances of EDIL3 in tumor

Ke Bin, Li Bin, Liang Han   

  1. Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy of Tianjin; Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
  • Online:2019-11-08 Published:2019-12-26
  • Contact: Liang Han E-mail:tj_lianghan@126.com
  • Supported by:
     National Natural Science Foundation of China (81401952); Science and Technology Research Project of Tianjin Municipal Health Bureau (2014KZ082)

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摘要： 表皮生长因子样重复盘状结构Ⅰ样域蛋白3（EDIL3）是一种内皮细胞合成分泌的细胞外基质蛋白，在胚胎发育、血管生成和抑制炎症反应等方面起关键作用。近年来研究发现EDIL3在胰腺癌、肝癌、结直肠癌、肺癌、乳腺癌等多种肿瘤中异常表达，并通过影响肿瘤细胞增殖、凋亡、侵袭转移和血管生成等，广泛参与肿瘤的发生、进展和转移过程，EDIL3的异常表达有望为肿瘤的诊断和治疗提供新的方法。

关键词: 肿瘤, 血管生成, 细胞凋亡, 表皮生长因子样重复盘状结构Ⅰ样域蛋白3

Abstract: Epidermal growth factor (EGF)-like repeat and discoidin Ⅰ-like domain 3 (EDIL3) is a extracellular matrix  protein that produced and secreted by endothelial cells and plays important roles in embryonic development, angiogenesis, and limit inflammation. Several recent studies indicate that EDIL3 is aberrantly expressed in pancreatic cancer, liver cancer, colorectal cancer, lung cancer and breast cancer, which is associated with cell proliferation, apoptosis, invasion, metastasis, and angiogenesis. EDIL3 is widely participated in the regulating tumor initiation, progression and metastasis, and its abnormal expression is expected to provide a new method for diagnosis and therapy of cancers.

Key words: Neoplasms, Angiogenesis, Apoptosis, EGF-like repeat and discoidin Ⅰ-like domain 3