国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (8): 487-489.doi: 10.3760/cma.j.issn.1673422X.2018.08.008

• 综述 • 上一篇    下一篇

CD70/CD27通路参与的免疫调节及CD70在肿瘤中的表达

刘珍珍,孔英君,孙文学,李世敏,张敏,殷和松   

  1. 150001 哈尔滨医科大学附属第一医院呼吸内科
  • 出版日期:2018-08-08 发布日期:2018-11-01
  • 通讯作者: 孔英君，Email: kyjtoday@sina.com E-mail:kyjtoday@sina.com

Immunological regulation of CD70/CD27 pathway and the expression of CD70 in tumor

Liu Zhenzhen, Kong Yingjun, Sun Wenxue, Li Shimin, Zhang Min, Yin Hesong   

  1. Department of Respiratory Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • Online:2018-08-08 Published:2018-11-01
  • Contact: Kong Yingjun E-mail:kyjtoday@sina.com

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摘要：  CD70/CD27通路在人类免疫调节中扮演着重要的角色，其在免疫调节中的作用主要表现在促进T细胞的活化与增殖，诱导效应T细胞和记忆T细胞的分化与形成以及对调节性T细胞的干预上。另外在某些肿瘤细胞中，CD70高水平表达为肿瘤的免疫治疗提供了新的思路。

关键词: 免疫, 细胞, 肿瘤, CD70/CD27通路

Abstract: CD70/CD27 pathway plays an important role in human immune regulation. The role of CD70/CD27 pathway in immune regulation is mainly to promote the activation and proliferation of T cells, induce the differentiation and formation of effector T cells and memory T cells, and interfere with regulatory T cells. In addition, the high level of CD70 expression in some tumor cells provides a new way for tumor immunotherapy.

Key words: Immunity, cellular, Neoplasms, CD70/CD27 pathway