国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (4): 193-196.doi: 10.3760/cma.j.issn.1673-422X.2018.04.001

• 论著 •    下一篇

口腔舌鳞状细胞癌患者血清多配体聚糖-1表达水平及临床意义

郝瑞,梁艳   

  1. 710004 西安市第四医院口腔科（郝瑞）
  • 出版日期:2018-04-08 发布日期:2018-05-16
  • 通讯作者: 郝瑞，Email: hrui323@163.com E-mail: hrui323@163.com

Expression level and clinical significance of serum syndecan-1 in oral tongue squamous cell carcinoma patients

Hao Rui, Liang Yan   

  1. Department of Stomatology, Fourth Hospital of Xi′an, Xi′an 710004, China
  • Online:2018-04-08 Published:2018-05-16
  • Contact: Hao Rui, Email: hrui323@163.com E-mail: hrui323@163.com

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摘要： 目的检测口腔舌鳞状细胞癌（OTSCC）患者血清多配体聚糖-1水平，探讨血清多配体聚糖-1在诊断OTSCC及评估疾病进展中的作用。方法收集2015年3月至2017年6月西安市第四医院收治的OTSCC患者65例（OTSCC组）和健康者74例（对照组）血清。酶联免疫吸附法检测血清多配体聚糖-1水平。受试者工作特征（ROC）曲线分析血清多配体聚糖-1对OTSCC及其疾病进展的诊断价值。结果OTSCC组血清多配体聚糖-1水平显著低于对照组［（91.87±33.18）ng/ml∶（162.32±51.16）ng/ml，t=1.977，P=0.002］。OTSCC组不同TNM分期（F=3.536，P=0.025）、浸润深度（F=1.254，P=0.039）、淋巴结转移（t=2.420，P=0.018）患者血清多配体聚糖-1水平差异均具有统计学意义。ROC曲线分析显示，血清多配体聚糖1对OTSCC的诊断最佳临界值为95.54 ng/ml［曲线下面积(AUC)=0.944，P＜0.001，95%CI为0.915～0.974］；对OTSCC患者是否有淋巴结转移的诊断最佳临界值为74.54 ng/ml（AUC=0.783，P＜0.001，95%CI为0.697～0.867）。结论血清多配体聚糖-1表达水平在OTSCC患者中显著降低，可用于诊断OTSCC及其是否有淋巴结转移，值得临床推广应用。

关键词: 肿瘤, 鳞状细胞, 口腔肿瘤, 舌肿瘤, 酶联免疫吸附测定, 诊断, 多配体聚糖1

Abstract: ObjectiveTo detect the level of serum syndecan-1 in patients with oral tongue squamous cell carcinoma (OTSCC), and to investigate the effect of serum syndecan-1 in OTSCC diagnosis and disease progression assessment. MethodsThe serums of a total of 65 OTSCC patients (OTSCC group) and 74 healthy subjects (control group) were collected from March 2015 to June 2017 in the Fourth Hospital of Xi′an. Enzyme linked immunosorbent assay was used to detect the level of serum syndecan-1. Receiver operating characteristic (ROC) curve was conducted to evaluate the diagnostic value of serum syndecan-1 in OTSCC and its disease progression. ResultsThe level of serum syndecan1 in OTSCC group was significantly lower than that in the control group ［(91.87±33.18)ng/ml vs. (162.32±51.16)ng/ml, t=1.977, P=0.002］. The serum syndecan-1 levels of different TNM stage (F=3.536, P=0.025), tumor invasive depth (F=1.254, P=0.039) and lymph node metastasis (t=2.420, P=0.018) in OTSCC group had statistically significances. ROC curve analysis showed that 95.54 ng/ml serum syndecan-1 ［area under the curve (AUC)=0.944, P＜0.001, 95%CI: 0.915-0.974］ was the cutoff value of OTSCC diagnosis, and 74.54 ng/ml of lymph node metastasis in OTSCC diagnosis (AUC=0.783, P＜0.001, 95%CI: 0.697-0.867). ConclusionSerum syndecan-1 level is markedly decreased in patients with OTSCC, and is valuable to diagnose OTSCC or its lymph node metastasis, which is worthy of clinical application.

Key words: Neoplasms, squamous cell, Mouth neoplasms, Tongue neoplasms, Enzyme-linked immunosorbent assay, Diagnosis, Syndecan-1