国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 672-675.doi: 10.3760/cma.j.issn.1673422X.2017.09.007

• 综述 • 上一篇    下一篇

适配子在肿瘤干细胞研究中的应用

彭勇华,彭立,梁志满,张兴梅   

  1. 510515 广州，南方医科大学基础医学院神经生物学教研室
  • 出版日期:2017-09-08 发布日期:2017-10-31
  • 通讯作者: 张兴梅 E-mail:zxmray@hotmail.com
  • 基金资助:

     国家自然科学基金（81272509）

Application of aptamer in the study of cancer stem cells

Peng Yonghua, Peng Li, Liang Zhiman, Zhang Xingmei   

  1. Department of Neurobiology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China
  • Online:2017-09-08 Published:2017-10-31
  • Contact: Zhang Xingmei E-mail:zxmray@hotmail.com
  • Supported by:

     National Natural Science Foundation of China (81272509)

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摘要： 肿瘤干细胞具有自我更新和多向分化潜能，在肿瘤生成、转移、复发和放化疗抗性等方面起着重要作用，是近年来肿瘤研究的热点。适配子是小分子寡核苷酸，具有极强的靶向性和亲和力，是肿瘤诊断和治疗的新型核酸分子。目前利用适配子进行肿瘤干细胞的诊断和治疗的研究越来越多，为肿瘤的诊断和治疗提供新的研究工具。

关键词: 肿瘤干细胞, SELEX适体技术, 肿瘤

Abstract: Cancer stem cells have selfrenewal and multilineage differentiation potentials, which play important roles in tumorigenesis, metastasis, recurrence and resistance to chemical therapy and radiotherapy, and so on. It is the hotspot of tumor research recently. Aptamer is a small molecular oligonucleotide with high targeting ability and affinity, which is a new type of nucleic acid in the diagnosis and treatment of cancer. Now more and more research is being done on the aptamer is applied in the diagnosis and treatment of cancer stem cells, which provides a new research tool for the diagnosis and treatment of cancer stem cells.

Key words: Neoplastic stem cells, SELEX aptamer technique, Neoplasms