程序性细胞死亡因子4在肿瘤中的研究进展

doi:10.3760/cma.j.issn.1673-422X.2017.07.008

摘要/Abstract

摘要： 程序性细胞死亡因子4（PDCD4）为新近发现的抑癌基因，其表达受PDCD4基因甲基化、多种微小RNA的抑制。PDCD4编码的蛋白质可增强多种肿瘤细胞对抗肿瘤药物的敏感性，抑制肿瘤的发生发展和侵袭转移进程，在多种肿瘤中发挥重要作用，有望成为临床上判断肿瘤预后的重要指标。

关键词: 肿瘤, 程序性细胞死亡因子4

Abstract: Programmed cell death 4 (PDCD4) is a newly discovered tumor suppressor gene, whose expression is regulated by methylation of PDCD4 gene and many kinds of microRNAs. Protein of PDCD4 encoding can improve the sensitivity of tumor cells to anticancer agents, inhibit tumor development and metastasis process, and play an important role in a variety of tumors. It is expected to be a clinical indicator to determine the prognosis of tumor.

Key words: Neoplasms, Programmed cell death 4

赵莉莉，张梅，朱耀东. 程序性细胞死亡因子4在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2017, 44(7): 512-515.

Zhao Lili, Zhang Mei, Zhu Yaodong. Research progress of programmed cell death 4 in tumors[J]. Journal of International Oncology, 2017, 44(7): 512-515.

参考文献

［1］ Soejima H, Miyoshi O, Yoshinaga H, et al. Assignment of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization［J］. Cytogenet Cell Genet, 1999, 87(12): 113-114. DOI: 15408. ［2］ Waters LC, Strong SL, Ferlemann E, et al. Structure of the tandem MA3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor［J］. J Biol Chem, 2011, 286(19): 1727017280. DOI: 10.1074/jbc.M110.166157. ［3］ Fan H, Zhao Z, Quan Y, et al. DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC7721［J］. Eur J Gastroenterol Hepatol, 2007, 19(11): 952961. DOI: 10.1097/MEG.0b013e3282c3a89e. ［4］ Gao F, Wang X, Zhu F, et al. PDCD4 gene silencing in gliomas is associated with 5′CpG island methylation and unfavourable prognosis［J］. J Cell Mol Med, 2009, 13(10): 4257-4267. DOI: 10.1111/j.15824934.2008.00497.x. ［5］孙娜. DNMT1和PDCD4在胃癌及癌前病变中的表达及其临床意义［D］. 济南: 山东大学, 2012. ［6］李日恒, 杨瑞红, 宋艳敏, 等. 结直肠癌组织中PAQR3、PDCD4基因甲基化水平与结直肠癌的关系［J］. 中国老年学杂志, 2015, 35(13): 3633-3635. DOI: 10.3969/j.issn.1005-9202.2015.13.069. ［7］ Sekar D, Krishnan R, Thirugnanasambantham K, et al. Significance of microRNA 21 in gastric cancer［J］. Clin Res Hepatol Gastroenterol, 2016, 40(5): 538-545. DOI: 10.1016/j.clinre.2016.02.010. ［8］ Cao Z, Yoon JH, Nam SW, et al. PDCD4 expression inversely correlated with miR21 levels in gastric cancers［J］. J Cancer Res Clin Oncol, 2012, 138(4): 611-619. DOI: 10.1007/s00432-011-1140-8. ［9］ Wen SW, Zhang YF, Li Y, et al. Characterization and effects of miR21 expression in esophageal cancer［J］. Genet Mol Res, 2015, 14(3): 8810-8818. DOI: 10.4238/2015.August.3.4. ［10］ Peacock O, Lee AC, Cameron F, et al. Inflammation and miR21 pathways functionally interact to downregulate PDCD4 in colorectal cancer［J］. PLoS One, 2014, 9(10): e110267. DOI: 10.1371/journal.pone.0110267. ［11］ Frampton AE, Castellano L, Colombo T, et al. Integrated molecular analysis to investigate the role of microRNAs in pancreatic tumour growth and progression［J］. Lancet (London, England), 2015, 385(Suppl 1): S37. DOI: 10.1016/S0140-6736(15)60352-X. ［12］ Frampton AE, Castellano L, Colombo T, et al. MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression［J］. Gastroenterology, 2014, 146(1): 268277, e18. DOI: 10.1053/j.gastro.2013.10.010. ［13］ Yang M, Liu R, Li X, et al. miRNA183 suppresses apoptosis and promotes proliferation in esophageal cancer by targeting PDCD4［J］. Mol Cells, 2014, 37(12): 873-880. DOI: 10.14348/molcells.2014.0147. ［14］ Ren LH, Chen WX, Li S, et al. MicroRNA-183 promotes proliferation and invasion in oesophageal squamous cell carcinoma by targeting programmed cell death 4［J］. Br J Cancer, 2014, 111(10): 2003-2013. DOI: 10.1038/bjc.2014.485. ［15］ Gu W, Gao T, Shen J, et al. MicroRNA-183 inhibits apoptosis and promotes proliferation and invasion of gastric cancer cells by targeting PDCD4［J］. Int J Clin Exp Med, 2014, 7(9): 2519-2529. ［16］ Lu YY, Zheng JY, Liu J, et al. miR-183 induces cell proliferation, migration, and invasion by regulating PDCD4 expression in the SW1990 pancreatic cancer cell line［J］. Biomed Pharmacother, 2015, 70: 151-157. DOI: 10.1016/j.biopha.2015.01.016. ［17］ Lei Y, Hu X, Li B, et al. miR150 modulates cisplatin chemosensitivity and invasiveness of muscleinvasive bladder cancer cells via targeting PDCD4 in vitro［J］. Med Sci Monit, 2014, 20: 1850-1857. DOI: 10.12659/MSM.891340. ［18］ Ning FL, Wang F, Li ML, et al. MicroRNA182 modulates chemosensitivity of human nonsmall cell lung cancer to cisplatin by targeting PDCD4［J］. Diagn Pathol, 2014, 9: 143. DOI: 10.1186/1746-1596-9-143. ［19］ Li H, Xu H, Shen H, et al. microRNA106a modulates cisplatin sensitivity by targeting PDCD4 in human ovarian cancer cells［J］. Oncol Lett, 2014, 7(1): 183188. DOI: 10.3892/ol.2013.1644. ［20］ Wei X, Wang W, Wang L, et al. MicroRNA21 induces 5fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4［J］. Cancer Med, 2016, 5(4): 693-702. DOI: 10.1002/cam4.626. ［21］ Xu H, Dephoure N, Sun H, et al. Proteomic profiling of paclitaxel treated cells identifies a novel mechanism of drug resistance mediated by PDCD4［J］. J Proteome Res, 2015, 14(6): 24802491. DOI: 10.1021/acs.jproteome.5b00004. ［22］王汉卿, 孙震晓. 抑癌基因Pdcd4的表达对羟基喜树碱细胞毒活性的影响［J］. 世界华人消化杂志, 2009, 17(7): 647-651. DOI: 10.3969/j.issn.1009-3079.2009.07.003. ［23］ Fassan M, Cagol M, Pennelli G, et al. Programmed cell death 4 protein in esophageal cancer［J］. Oncol Rep, 2010, 24(1): 135-139. ［24］ Fassan M, Pizzi M, Battaglia G, et al. Programmed cell death 4 (PDCD4) expression during multistep Barrett′s carcinogenesis［J］. J Clin Pathol, 2010, 63(8): 692-696. DOI: 10.1136/jcp.2010.078253. ［25］ Yu H, Zeng J, Liang X, et al. Helicobacter pylori promotes epithelialmesenchymal transition in gastric cancer by downregulating programmed cell death protein 4 (PDCD4)［J］. PLoS One, 2014, 9(8): e105306. DOI: 10.1371/journal.pone.0105306. ［26］ Liang H, Wang F, Chu D, et al. miR93 functions as an oncomiR for the downregulation of PDCD4 in gastric carcinoma［J］. Sci Rep, 2016, 6: 23772. DOI: 10.1038/srep23772. ［27］ Wang LY, Zhao MS, Guo C, et al. PDCD4 deficiency aggravated colitis and colitisassociated colorectal cancer via promoting IL6/STAT3 pathway in mice［J］. Inflamm Bowel Dis, 2016, 22(5): 11071118. DOI: 10.1097/MIB.0000000000000729. ［28］ Liu Y, Guo Y, Liang H, et al. miR181b functions as an oncomiR in colorectal cancer by targeting PDCD4［J］. Protein Cell, 2016, 7(10): 722-734. DOI: 10.1007/s13238-016-0313-2.

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